TY - JOUR AU - Teerawanittrakul, Penmas AU - Jianbunjongkit, Narit AU - Intrarak, Thanavit PY - 2021/03/10 Y2 - 2024/03/29 TI - A Comparison of Intranasal 0.05% Oxymetazoline and Intranasal 3% Ephedrine for Reducing Nasal Congestion: A Double-Blind Randomized Controlled Trial JF - Journal of The Department of Medical Services JA - J DMS VL - 45 IS - 4 SE - Original Article DO - UR - https://he02.tci-thaijo.org/index.php/JDMS/article/view/249823 SP - 236-242 AB - <p><strong>Background</strong> : There are many drugs that used to reduce nasal congestion, both oral and nasal spray. Nasal sprays divided into 2 groups: the beta phenylethylamime derivatives and midazoline derivatives and there are no comparative study of the effectiveness of these two drugs to reduce nasal congestion.</p><p><strong> Objective</strong> : to evaluating the efficacy of using intranasal 0.05% oxymetazoline, and intranasal 3% ephedrine to reduce nasal congestion.</p><p><strong> Method</strong> : A double-blinded randomized controlled trial was conducted in 84 patients ages ranging from 18 to 60 years with nasal congestion at the Department of Otolaryngology, Burapha University Hospital from January to April 2020. The level of nasal relief was measured by Peak Nasal Inspiratory Flow (PNIF) before and after using the intranasal spray 10 minute,Visual Analogue Scale was measured before and after using the intranasal spray 10, 30 minute. Then descriptive statistics and independent Paired t-Test were applied to analyze the data.</p><p><strong>Results</strong> : The 84 patients (49 female, 35 male) with an average age of 39.54 years revealed that the level of PNIF measured before and after spraying 0.05% oxymetazoline and 3% ephedrine were statistically significant difference. (p-value &lt; 0.005, 95% CI = -49.74, -26.45 and p-value &lt; 0.005, 95% CI = -50.72, -31.42, respectively). The visual analog scale recorded before and after spraying 0.05% oxymetazoline and 3% ephedrine also showed a statistically significant difference (p-value &lt; 0.005, 95% CI = 1.523, 2.287 and p-value &lt; 0.005, 95% CI = 2.656, 3.535 respectively). The measuring PNIF at 10 minutes after using the intranasal spray illustrated that both drugs could increase the level of nasal relief. However, a non-significant difference was reported when comparing these two drugs (p-value = 0.847, 95% CI = -19.9, 24.2).&nbsp;</p><p><strong>Conclusion</strong> : the two drugs cloud reduce the blockage of the nasal passage, physicians may consider using them after deliberating other factors.</p> ER -