The Effect of Oropharyngeal Colostrum Administration on Immunoglobulin A in Preterm Infants

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Kritsadaporn Lobbamrung
Tipawan Daramas
Jariya Wittayasooporn



         The present study was a quasi-experimental reseach to investigate the effect of oropharyngeal administration of colostrum on the levels of immunoglobulin A in preterm infants with gestational age less than 32 weeks, who were admitted into neonatal ward at Queen Sirikit National Institute of Child Health. The 10 preterm infants were recruited based on the inclusion criteria. The preterm infants received oral administration 0.2 ml of colostrum every three hours for 7 consecutive days. The oral administration began within 48 hours after birth. The secretory immunoglobulin A (sIgA) in urine was measured before oropharyngeal administration of colostrum within 24 hours after birth and after oropharyngeal administration of colostrum on the 5 th and 14th days after birth. Difference in the average of sIgA in urine was determined with the one-way repeated measure ANOVA. The result showed that the average level of sIgA in urine of the preterm infants before oropharyngeal administration of colostrum within 24 hours after birht was 117.47 ng/mL and after oropharyngeal admonistration of colostrum on the 5th and 14th days after birth was 101.97 ng/mL and 809.96 ng/mL, However, the average of sIgA in urine of pretern infants before and after oropharyngeal administration of colostrum were no statistical significant difference (p < .05). Limitation of this study used a small sample group, it is recommended that more research using a bigger sample shoud be done to better understand the relationship of the levels of sIgA in preterm infants, receiving oropharyngeal administrion of colostrum, providing care to preterm infants.


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Lobbamrung K, Daramas T, Wittayasooporn J. The Effect of Oropharyngeal Colostrum Administration on Immunoglobulin A in Preterm Infants. Rama Nurs J [Internet]. 2019 Apr. 17 [cited 2022 Aug. 10];25(1):16-28. Available from:


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