Thai Journal of Dermatology

Corrigendum to “Identification if a New FLCN Variant in a Patient with Suspected Birt-Hogg-Dubé Syndrome Presented with Cutaneous Late-Onset Angiofibroma”

Thanyasak Bespinyowong — 2026-04-27

Vol. 40 No. 3 (2024): July - September 2024

https://he02.tci-thaijo.org/index.php/TJD/article/view/268115

Corrigendum

Corrigendum to “Identification if a New FLCN Variant in a Patient with Suspected Birt-Hogg-Dubé Syndrome Presented with Cutaneous Late-Onset Angiofibroma” [Thai J Dermatol 2024; 40: 81-84]

Received 23 February 2026; Accepted 1 March 2026

Thanyasak Bespinyowong, Tanattrin Bunnag, Chavalit Supsrisunjai,

“Identification if a New FLCN Variant in a Patient with Suspected Birt-Hogg-Dubé Syndrome Presented with Cutaneous Late-Onset Angiofibroma,” Thai J Dermatol 2024; 40: 81-84

The authors regret to inform that the original version of this article contained errors in the title and the author list. The title was incorrectly published as “Identification if a New FLCN Variant in a Patient with Suspected Birt-Hogg-Dubé Syndrome Presented with Cutaneous Late-Onset Angiofibroma”, whereas the correct title should read “Identification of a New FLCN Variant in a Patient with Suspected Birt-Hogg-Dubé Syndrome Presented with Cutaneous Late-Onset Angiofibroma.”

Additionally, the second author’s name was erroneously listed as Tanattrin Bunnag; the correct name is Thareena Bunnag.

The authors sincerely apologize for these errors and any inconvenience caused to the readers.

A Rare Case of Hallopeau-Type Pemphigus Vegetans with Premalatha Sign: A Case Report and Literature Review

Kanokkorn Yuttaworavit — 2026-04-27

Pemphigus vegetans (PVeg) is the rarest clinical variant in the pemphigus group of vesiculobullous autoimmune diseases, accounting for less than 2% of all pemphigus cases.¹ It is classified into two subtypes: Hallopeau and Neumann, which differ in severity and prognosis. PVeg presents with flaccid bullae or pustules that break down into thickened, papillated plaques, mainly involving the skin folds, scalp, face, and mucous membranes. In some cases, oral lesions may resemble the surface of the brain, a distinctive feature known as the Premalatha sign. The diagnosis of PVeg relies on a combination of clinical presentations, histopathological findings, and laboratory investigations.

We reported a case of PVeg characterized by involvement of skin folds, oral ulcers, and a cerebriform tongue (Premalatha sign). A tissue sample taken from a lesion in the right groin revealed papillomatous hyperplasia of the epidermis, suprabasal separation with acantholytic cells, and intraepidermal abscesses, consistent with a classic presentation of PVeg. Direct immunofluorescence revealed IgG deposits in the intercellular spaces of the epidermis, while indirect immunofluorescence detected a high titer of pemphigus IgG autoantibodies. Additionally, the anti-desmoglein 3 antibody test was positive. The patient received a three-month regimen of prednisolone and azathioprine, leading to successful treatment without relapse. This outcome confirmed the diagnosis of Hallopeau-type PVeg, which is linked to a more favorable prognosis.

Systematized epidermal nevus: A case report

Tippawan Boonseree — 2026-04-27

Systematized epidermal nevus (SEN) is an extensively distributed variant of keratinocytic epidermal nevi. The clinical features include bilateral well-defined skin-colored to hyperpigmented verrucous or velvety papules that coalesce to form plaques in a Blaschkoid distribution. We report a case of SEN in an eight-year-old Thai boy. He presented with multiple brownish hyperkeratotic papules and plaques on his face, neck, chest, and back arranged along the lines of Blaschko with no evidence of systemic involvement. The diagnosis was supported by clinical manifestations and histopathological features. The patient received multiple sessions of carbon dioxide (CO₂) laser. Long-term follow-up is necessary throughout the patient’s lifetime, as neurological manifestations may present later in adulthood.

The Assessment of Depression Among Psoriasis Patients in a Southern Regional Hospital of Tropical Dermatology Trang Province, Thailand

Siriporn Saenghirun — 2026-04-27

Background: Psoriasis is a chronic, immune-mediated skin disorder that is influenced by both genetic susceptibility and environmental factors. Psoriasis affects the quality of life of the patient not only physically, but also mentally. Because psoriasis is a chronic skin disease that cannot be completely cured without relapsing, it may cause individuals to develop depression.

Objective: To screen for depression in psoriasis patients receiving services at the Southern Tropical Dermatology Hospital, Trang Province (Hospital of Tropical Dermatology).

Materials and Methods: This study employed a cross-sectional descriptive design. Data was gathered using a structured, face-to-face interview questionnaire comprising the 2Q, 9Q, and 8Q formats. The data were analyzed using descriptive statistics.

Results: In the depression screening of 186 participants, the median psoriasis duration was 5 (3, 10) years. Using the 2Q questionnaire, depression was found to be a potential outcome in 29 patients (15.6%). Using the 9Q screening questionnaire, 24 patients with psoriasis (12.9%) were found to have very mild depression, while 5 patients (2.7%) had mild depression. Of these 5, 4 patients (80.0%) had mild psoriasis, and 1 patient (20.0%) had moderate psoriasis. In terms of overall suicidal tendency, 3 patients (1.6%) were found to have a low tendency for suicide attempts.

Conclusion: In the hospital, few cases of depression were found; however, screening for depression is recommended for patients with psoriasis.

Factors Associated with Postherpetic Neuralgia among Thai Patients with Herpes Zosterat the Dermatology Clinic, Siriraj Hospital: A Retrospective Cohort Study

Sukhum Jiamton — 2026-04-27

Introduction: Herpes Zoster (HZ) is caused by the reactivation of latent varicella zoster virus in the sensory ganglia following an outbreak of chickenpox. The aim of this study was to evaluate the characteristics of HZ in Thai patients.

Objective: To describe the clinical characteristics of patients with HZ attending the outpatient dermatology clinic at Siriraj Hospital.

Materials and Methods: This retrospective cohort study included patients diagnosed with HZ at the Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand between December 2015 and December 2016. Data on patients’ characteristics, underlying diseases, clinical manifestations, affected sites, treatments, and complications were obtained from medical records.

Results: A total of 432 patients with HZ were included. The mean age was 57.7 years, with a predominance of female patients (59.0%). The most commonly affected dermatome was thoracic (35.0%). Postherpetic neuralgia (PHN) was the most frequent complication (18.8%) and was significantly associated with older age (64.2 vs. 56.8 years, P < 0.001), female gender (69.1% vs. 56.6%, P = 0.038), presence of comorbidities (75.3% vs. 60.6%, P = 0.013), and gabapentin use (60.8% vs. 37.5%, P < 0.001).

Conclusions: This study highlights the demographic and clinical characteristics of HZ among Thai patients. PHN was significantly more common in older patients, females, and those with comorbidities. The increased use of gabapentin in PHN cases reflects its role in standard clinical management. These findings may support early antiviral treatment and targeted prevention strategies in high-risk groups.

Impact of Adult Psoriasis on Caregiver’s Quality of Life: Role of Caregiver Sex and Patient Special Area Involvement

Chalermkwan Apinuntham — 2026-04-27

Background: Psoriasis has an impact on both the patient’s life and on family members, particularly those who serve as primary caregivers. To study the impact of psoriasis on the quality of life (QoL) of caregivers using the Family Dermatology Life Quality Index (FDLQI) and exploring factors associated with it.

Materials and methods: Adult patients with psoriasis were matched 1:1 with a caregiver or family member– defined as the primary person who regularly cares for the patient, lives in the same household, and is actively involved in daily care. Demographic data and FDLQI scores were collected.

Results: Fifty-two patients with psoriasis and 52 caregivers/family members were enrolled. Most of the patients were cared for by a first-degree relative (57.7%) or a spouse (34.6%), followed by other relatives (3.8%) and cohabitants (3.8%). Psoriasis had the greatest impact on caregiver QoL in the areas of time spent caring for the patient’s skin (1.6 ± 1.1 points), extra housework (1.4 ± 1.2 points), and household expenditure (1.2 ± 1.0 points). However, there were no significant differences between female and male caregivers in any of the items of the FDLQI. The FDLQI score was significantly associated with patients’ QoL (r=0.59, p <0.01) and the Psoriasis Area and Severity Index score (r=0.50, p <0.01), and body surface area involvement (r=0.47, p <0.01). Furthermore, caregivers of patients with psoriasis that affects the scalp (p=0.001), face (p=0.005), nails (p<0.001) and intertriginous area (p=0.032) had significantly higher median FDLQI scores compared to those without psoriasis in these areas.

Conclusion: This study found that the severity of disease, the QoL of patients, and the psoriasis affecting special areas all significantly impact the QoL of caregivers. However, no significant differences were observed based on caregiver sex. Understanding these impacts is important to achieve the best outcome for patients with psoriasis.