Thai Journal of Dermatology

Subcutaneous Basidiobolomycosis: A Report of Young Thai Lady

Chachrist Tuchinda — 2024-09-06

Subcutaneous basidiobolomycosis is a rare chronic granulomatous infection caused by Basidiobolus ranarum. We present the case of a 22-year-old Thai woman who, without a history of trauma, presented with painless masses extending from the left flank to the left thigh over the course of one year. Notably, the condition failed to respond to a six-month course of anti-tuberculosis medication. Subsequent investigations, including skin biopsy, tissue culture, and polymerase chain reaction, conclusively confirmed the diagnosis of subcutaneous basidiobolomycosis. Remarkably, neither clinical assessments nor imaging revealed involvement of other organs except for left posterior gluteus maximus and left lateral tensor fascia latae muscle. The patient achieved complete resolution following a two-month administration of itraconazole at a dosage of 400mg per day.

Deep Vein Thrombosis Related with Henoch-Schönlein Purpura in Pediatric Patient

Sirada Srithanetsakul — 2024-09-06

Henoch-Schönlein Purpura is a condition within the vasculitis groups. It can result in manifestations, including abdominal discomfort, kidney problems, joint inflammation, and palpable purpura. In some instances, it may even lead to the development of thrombosis. An illustrative case involved a boy diagnosed with Henoch-Schönlein Purpura who experienced vein thrombosis in both legs. The patient experienced an improvement in his symptoms after receiving enoxaparin and colchicine.

Dual Improvements in Dermatological Symptoms and Psychological Well-Being of Psoriasis Patients After Treatment with a Single Dose of Secukinumab: Three Case Reports

Pajaree Khemachit — 2024-09-06

Psoriasis is a chronic inflammatory skin condition that significantly impacts the physical and psychological well-being of affected individuals. It is characterized by well-demarcated, erythematous plaques with a white scaly surface. Beyond its dermatological manifestations, psoriasis is associated with systemic comorbidities, including arthritis, metabolic syndrome, cardiovascular diseases, and notably, psychological disorders such as depression and anxiety. We report a case series of patients suffering from moderate to severe psoriasis with concurrent mild to moderate depression. Patients administered with a single dose of 300 mg secukinumab, an interleukin-17 antagonist, showed significant improvements in psoriasis symptoms, quality of life, and depression levels within an 8-week period. This dual benefit underscores the importance of an integrated approach to managing patients with psoriasis, addressing both dermatological and psychological aspects.

Identification if a New FLCN Variant in a Patient with Suspected Birt-Hogg-Dubé Syndrome Presented with Cutaneous Late-Onset Angiofibroma

Thanyasak Bespinyowong — 2024-09-06

A 63-year-old female presented with a 40-year history of multiple skin-colored facial papules with previous medical history of two episodes of spontaneous pneumothorax at the age of 28 and 62 years. Multiple cysts in both lungs were detected by high-resolution computed tomography chest. Physical examination revealed multiple skin-colored facial papules on her nose and malar area. Sanger sequencing of FLCN showed a new heterozygous mutation, c.1448T>C, p.Leu483Pro, potentially resulting in abnormally functioning protein. Even in the absence of characteristic skin histology, the diagnosis was made using one major criterion (FLCN germline mutation) and one minor criterion (many lung cysts) in accordance with the European Birt-Hogg-Dubé Syndrome Consortium diagnostic criteria⁶

The Chik Sign – Unmasking Chikungunya through Facial Pigmentation – A Case Report

Sonia P Jain — 2024-09-06

The "Chik Sign," which is a distinctive facial pigmentation pattern associated with Chikungunya fever, aids in prompt clinical diagnosis. A 38-year-old woman presented with complaints of facial pigmentation and had a history of severe joint pain. Dermatoscopic examination supported the diagnosis of Chikungunya, underscoring the significance of early recognition. This case highlights the importance of considering Chikungunya in dermatological presentations of facial pigmentation.