Correlation between hydronephrosis, tumor diameter, and pathologic T stage of upper tract transitional cell carcinoma after nephroureterectomy

  • Treerat Amornporncharoen Division of Urology, Department of Surgery, Rajavithi Hospital, Bangkok, Thailand
  • Nattapong Wongwattanasatien Division of Urology, Department of Surgery, Rajavithi Hospital, Bangkok, Thailand
  • Vorapoj Choonhaklai Division of Urology, Department of Surgery, Rajavithi Hospital, Bangkok, Thailand
  • Vorapoj Choonhaklai Division of Urology, Department of Surgery, Rajavithi Hospital, Bangkok, Thailand
  • Viroj Chittchang Division of Urology, Department of Surgery, Rajavithi Hospital, Bangkok, Thailand
  • Somkiet Pumpaisanchai Division of Urology, Department of Surgery, Rajavithi Hospital, Bangkok, Thailand
  • Tanet Thaidumrong Division of Urology, Department of Surgery, Rajavithi Hospital, Bangkok, Thailand
  • Sermsin Sindhubodee Division of Urology, Department of Surgery, Rajavithi Hospital, Bangkok, Thailand
  • Chawawat Kosrisirikul Division of Urology, Department of Surgery, Rajavithi Hospital, Bangkok, Thailand
  • Matchima Huabkong Division of Urology, Department of Surgery, Rajavithi Hospital, Bangkok, Thailand
Keywords: Hydronephrosis, tumor diameter, pathologic T stage, upper tract transitional cell carcinoma, nephroureterectomy

Abstract

Objective:  To evaluate the correlation between hydronephrosis, tumor diameter, and pT stage of upper tract transitional cell carcinoma.

Material and Method:  From October 2004 to December 2018, the medical records of 98 patients in Rajavithi Hospital who were diagnosed with renal pelvic
(47 patients) and ureteral (51 patients) transitional cell carcinoma and treated with nephroureterectomy were retrospectively reviewed. Patient demographics,
degree of hydronephrosis, tumor diameter from computed tomography, and pathologic report were collected. Data were analyzed to determine correlations.

Results:  In renal pelvic tumor, higher degree of hydronephrosis correlated with higher pT stage (p=0.022) but no significant difference was shown in ureteral
tumor (p=0.352). For tumor diameter in both renal pelvis and ureter, there were no correlations with pT stage (p=0.128 and p=0.625). For tumor location, higher pT stage was more common in renal pelvic tumors (p=0.001) and high tumor grade correlated with high pT stage (p=0.037).

Conclusion:  In this study, there was significant correlation between the preoperative degree of hydronephrosis and pT stage in renal pelvic transitional cell carcinomas; however, none was found in ureteric tumors. The reason may be that smaller ureteric lumen caused early symptoms, which concerned patients.

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References

Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin 2013;63:11-30.

Cosentino M, Palou J, Gaya JM, Breda A, Rodriguez-Faba O, Villavicencio-Mavrich H. Upper urinary tract urothelial cell carcinoma: location as a predictive factor for concomitant bladder carcinoma. World J Urol 2013;31:141-5.

Batata MA, Grabstald H. Upper urinary tract urothelial tumors. Urol Clin North Am 1976;3:79-86.

Cho KS, Hong SJ, Cho NH, Choi YD. Grade of hydronephrosis and tumor diameter as preoperative prognostic factors in ureteral transitional cell carcinoma. rology 2007;70:662-6.

Caoili EM, Cohan RH, Korobkin M, Platt JF, Francis IR, Faerber GJ, et al. Urinary tract abnormalities: Initial experience with multidetector row CT urography. Radiology 2002;222:353-60.

Scolieri MJ, Paik ML, Brown SL, Resnick MI. Limitations of computed tomography in the preoperative staging of upper tract urothelial carcinoma. Urology 2000;56:930-4.

Armine KS, Surena M, Thomas WJ. Urothelial Tumors of the upper urinary tract and ureter. In: Wein AJ, Kavoussi LR, Partin AW, Peters CA, editors. Campbell-Walsh Urology, 11th Ed. Philadelphia: Elsevier Saunders; 2016: p.1365-402.

Png KS, Lim EK, Chong KT, Sugiono M, Yip SK, Cheng CW. Prognostic factors for upper tract transitional cell carcinoma: a retrospective review of 66 patients. sian J Surg 2008;31:20-4.

Favaretto RL, Shariat SF, Chade DC, Godoy G, Adamy A, Kaag M, et al. The effect of tumor location on prognosis in patients treated with radical ephroureterectomy at Memorial Sloan-Kettering Cancer Center. Eur Urol 2010;58:574-80.

Hall MC, Womack S, Sagalowsky AI, Carmody T, Erickstad MD, Roehrborn CG. Urology 1998;52:594-601.

Gerald AF, Helmut S, Hannes A, et al. Multiphasic multidetector-row CT (MDCT) in detection and staging of transitional cell carcinomas of the upper urinary tract. Eur Radiol 2006;16:1244-52.

Anderstrom C, Johansson SL, Pettersson S, Wahlqvist L. Carcinoma of the ureter: a clinicopathologic study of 49 cases. J Urol 1989;142:280-3.

Yujiro Ito, Eiji K, Nobuyuki T, Miyajima A, Mikami S, Jinzaki M, et al. Preoperative hydronephrosis grade independently predicts worse pathological outcomes in patients undergoing nephroureterectomy for upper tract urothelial carcinoma. J Urol 2011;185:1621-6.

Gordon AB, Surena FM, JE Busby, Dinney CP, Grossman HB, Pettaway CA, et al. Ability of clinical grade to predict final pathologic stage in upper urinary tract transitional cell carcinoma: implications for therapy. Urology 2007;70:252-6.

Published
2020-12-02
How to Cite
Amornporncharoen, T., Wongwattanasatien, N., Choonhaklai, V., Choonhaklai, V., Chittchang, V., Pumpaisanchai, S., Thaidumrong, T., Sindhubodee, S., Kosrisirikul, C., & Huabkong, M. (2020). Correlation between hydronephrosis, tumor diameter, and pathologic T stage of upper tract transitional cell carcinoma after nephroureterectomy. nsight rology, 41(2), 9-16. etrieved from https://he02.tci-thaijo.org/index.php/TJU/article/view/247833
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Original article

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