@article{Komuttarin_Poolthananant_2022, title={Validation of Euroscore II Cut-off at 12% for Active Infective Endocarditis}, volume={42}, url={https://he02.tci-thaijo.org/index.php/ThaiJSurg/article/view/250968}, abstractNote={<p><strong>Objective</strong>: Patients with infective endocarditis (IE) have a high risk of perioperative death. An accurate and reliable predictive score is crucial for decision making. The aim of this study is to externally validate Euroscore II, at a cut-off of 12%, in the prediction of hospital mortality.</p> <p><strong>Patients and Methods:</strong> Data were collected from medical records of patients who were diagnosed with active IE between June 1<sup>st</sup> 2017 and June 1<sup>st </sup>2020. Preoperative Euroscore II was calculated. Patients were categorized into 2 groups according to Euroscore II: those with scores < 12 and ≥ 12. The discriminatory ability using the cut-off value was determined from observed perioperative mortality.</p> <p><strong>Results:</strong> There were 43 patients diagnosed with active IE. None had prosthetic IE. Most were male (56%). The mean age was 47.7 years. Large vegetation was found in 89%. Only one patient had ejection fraction < 40%. The most common clinical manifestation was heart failure (81%). Around four-fifths had single valvular involvement (82%). The most affected site was the aortic valve (44%). Median time from diagnosis to surgery was 7.5 days. Median duration of aortic cross-clamp time and cardiopulmonary bypass time were 83 mins and 99 mins respectively. The mean Euroscore II was 8.6%. There was 7% mortality (3/43). All deaths occurred in patients with Euroscore II ≥ 12. By using cut-off value of Euroscore II at 12%, the area under the receiver operating characteristic curve was 91.3% (95% CI 85.3 – 97.2%).</p> <p><strong>Conclusion: </strong>This study confirmed the validity of using Euroscore II ≥ 12% to help discriminate high-risk active IE patients. It might be accurate enough to help decision making for surgery in high-risk active IE patients in centers with similar circumstances.</p>}, number={4}, journal={The Thai Journal of Surgery}, author={Komuttarin, Komkrit and Poolthananant, Nisit}, year={2022}, month={Jan.}, pages={167–173} }