TY - JOUR AU - Sukarayothin, Thongchai AU - Luadthai, Praweena AU - Chirappapha, Prakasit AU - Wasuthit, Yodying AU - Suvikapakornkul, Ronnarat AU - Kongdan, Youwanush AU - Lertsithichai, Panuwat PY - 2012/09/28 Y2 - 2024/03/28 TI - DCIS Diagnosed via Core Needle Biopsy: Upstaging Rate, Microinvasion and Axillary Lymph Node Metastasis JF - The Thai Journal of Surgery JA - Thai J Surg VL - 33 IS - 3 SE - Original Articles DO - UR - https://he02.tci-thaijo.org/index.php/ThaiJSurg/article/view/226882 SP - AB - <div><strong>Objective:</strong> To determine the upstaging rate of core needle-diagnosed ductal carcinoma in situ (DCIS) to<br>invasive breast cancer, as well as to identify risk factors for upstaging; and to relate DCIS with or without<br>microinvasion to the rate of axillary lymph node metastasis.</div><div><br><strong>Methods:</strong> Records of breast cancer patients with core needle biopsy (CNB) diagnosis of DCIS with or<br>without microinvasion who subsequently underwent definitive surgery during the years 2008 to 2010 were<br>reviewed. Data on clinical findings, mammographic findings, CNB findings, breast surgical procedures, axillary<br>lymph node procedures, nodal metastasis, and final pathological diagnosis were collected. Upstaging rates were<br>calculated and compared between DCIS groups and attempts were made to identify risk factors for upstaging<br>and axillary lymph node metastasis.</div><div><br><strong>Results:</strong> CNB-diagnosed pure DCIS were upstaged to any invasive breast cancer in 42% (25/59) of<br>patients, and to macro-invasive cancer only in 19% (11/59). DCIS with microinvasion was upstaged to macroinvasive<br>cancer in 34% (10/29). No risk factors were identified which could predict upstaging. Final diagnoses<br>of pure DCIS, DCIS with microinvasion and macro-invasive breast cancer were associated with axillary lymph<br>node metastasis rates of 0 (0/33), 5% (1/20) and 24% (5/21), respectively. No set of risk factors could identify<br>patients with a high likelihood of axillary metastasis.</div><div><br><strong>Conclusion:</strong> CNB-diagnosed DCIS with or without microinvasion had a relatively high upstaging rate. No<br>high-risk group for invasive cancer or axillary lymph node involvement could be identified.</div> ER -