Sensitivity and Specificity of Pronto Dry® for Diagnosis of Helicobacter Pylori Infection

Abstract

Sensitivity and Specificity of Pronto Dry^® for Diagnosis of Helicobacter Pylori Infection

Suphakan         Techapongsatorn         MD.*

Anan                 Manomaipiboon             MD., MSc (Clinical Epidemiology)*

Supot                Kaitwanidwilai                MD.*

General Surgery unit. Department of Surgery, Bangkok Metropolitan Administration Medical College and Vajira Hospital

Objective: To study sensitivity and specificity of urease test for Helicobacter pylori infection comparing with pathological finding.

Study design: Diagnostic test.

Setting: Division of General Surgery, Department of Surgery, Bangkok Metropolitan Administration Medical College and Vajira Hospital.

Subjects: Seventy six patients, older than 15 years old, with clinical symptoms of dyspepsia underwent gastroduodenoscopy between December 2002 to September 2003

Intervention: The mucosa of gastric antrum was biopsied for pathological examination and urease test (Pronto Dry®) to detect Helicobacter pylori infection

Main outcome measure: Helicobacter pylori infection.

Results: Among 76 patients, positive Helicobacter pylori from histopathological study was identifies in 25 patients (32.89%). In positive urease test, the color of the test was changes from yellow to red magenda. At 180 minutes, positive urease test was identifies in 29 patients (38.16%), Sensitivity and specificity of this urease test was 76% and 80.6% respectively with 95% CI was 76 + 9.8.

Conclusion: The urease test can be diagnostic test for Helicobacter pylori infection and the most appropriate time for urease test in this study to detect Helicobacter pylori infection was 180 minutes.

Key Words: Urease test, Helicobacter pylori infection

Vajira Med J 2005 ; 49 : 53 - 58