Is (ab) normal saline harmful?


  • เพชร วัชรสินธุ์ แผนกโรคทางระบบทางเดินหายใจและเวชบำบัดวิกฤต กองอายุรกรรม รพ.พระมงกุฎเกล้า


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Finfer S, Liu B, Taylor C, Bellomo R, Billot L, Cook D, et al. SAFE TRIPS Investigators. Resuscitation fluid use in critically ill adults: an international cross-sectional study in 391 intensive care units. Crit Care 2010;14:R185.

Kellum JA. Fluid resuscitation and hyperchloremic acidosis in experimental sepsis: improved short-term survival and acid-base balance with Hextend compared with saline. Crit Care Med 2002;30:300-5.

Scheingraber S, Rehm M, Sehmisch C, Finsterer U. Rapid saline infusion produces hypercholremic acidosis in patients undergoing gynecologic surgery. Anesthesiology 1999;90:1265-70.

Waters JH, Miller LR, Clack S, Kim JV. Cause of metabolic acido sis in prolonged surgery. Crit Care Med 1999;27:2142-6.

Hansen PB, Jensen BL, Skott O. Chloride regulates afferent arteriolar contraction in response to depolarization. Hypertension 1998;32:1066-70.

Chowdhury AH, Cox EF, Francis ST, Lobo DN. A randomized, controlled, double-blind crossover study on the effects of 2-L infusions of 0.9% saline and Plasma-Lyte 148 on renal blood flow velocity and renal cortical tissue perfusion in healthy volunteers. Ann Sur 2012;256:18-24.

Wilkes NJ, Woolf R, Mutch M, Mallett SV, Peachey T, Stephens R, et al. The effects of balanced versus saline-based hetastarch and crystalloid solutions on acid-base and electrolyte status and gastric mucosal perfusion in elderly surgical patients. Anesth Analg 2001;93:811-6.

Williums EL, Hildebrand KL, McCormick SA, Bedel MJ. The effect of intravenous lactated Ringer’s solution versus 0.9% sodium chloride solution on serum osmolality in human volunteers. Anesth Analg 1999;88:999-1003.

Morakul S, Karnjanarachata C, Pravitharangul T, Tangsujaritvijit V. Change in serum cholride level after loading dose of sterofundin solution compared with normal saline solution. J Med Assoc Thai 2018 [Epub ahead of print].

Raghunathan K, Shaw A, Nathanson B, Stürmer T, Brookhart A, Stefan MS, et al. Association between the choice of IV crystalloid and in-hospital mortality among critically ill adults with sepsis. Crit Care Med 2014;42:1585-91.

Young P, Bailey M, Beasley R, Henderson S, Mackle D, McArthur C, et al. Effect of a buffered crystalloid solution vs saline on acute kidney injury among patients in the intensive care unit: The SP LIT randomized clinical trial. JAMA 2015;314:1701-10.

Self WH, Semler MW, Wanderer JP, Wang L, Byrne DW, Collins SP, et al. Balanced crystalloid versus saline in non-critically ill adults. N Engl J Med 2018;378:819-28.

Semler MW, Self WH, Wanderer JP, Ehrenfeld JM, Wang L, Byrne DW, et al. Balanced crystalloids versus saline in critically ill adults. N Engl J Med 2018;378:829-39.

Shaw A. Models of preventable disease: contrast-induced nephropathy and cardiac surgery-associated acute kidney injury. Contrib Nephrol 2011;174:156-62.

Palevsky PM, Molitoris BA, Okusa MD, Levin A, Waikar SS, Wald R, et al. Design of clinical trials in acute kidney injury: report from an NIDDK workshop on trial methodology. Clin J Am Soc Nephrol 2 012;7:844-50.



How to Cite

วัชรสินธุ์ เ. Is (ab) normal saline harmful?. Clin Crit Care [Internet]. 2018 Dec. 31 [cited 2023 Mar. 26];26(2):31-5. Available from:



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