Anti-inflammatory agents other than corticosteroid in SARs-CoV-2 pneumonia

Authors

  • Pongdhep Theerawit Pulmonary and Critical Care Medicine, Ramathibodi Hospital, Mahidol University Bangkok, Thailand 10400

Keywords:

COVID-19, SARS-CoV-2, Corticosteroid, Anti-inflammatory agents, Pneumonia

Abstract

The SARs-CoV-2 results in hyperinflammation among infected patients. This condition leads to serious organ injury, especially in the lungs. Therefore, the main treatment option, in addition to anti-viral agents, is the administration of corticosteroids. However, in many cases, inadequate response to corticosteroids has been observed—other anti-inflammatory agents, such as interleukin-6 inhibitor, kinase inhibitor, etc., play an essential role in reducing this severe complication.

References

Gustine JN, Jones D. Immunopathology of Hyperinflammation in COVID-19. Am J Pathol. 2021; 191(1):4-17.

Fajgenbaum DC, June CH. Cytokine Storm. N Engl J Med. 2020 ;383(23):2255-2273.

RECOVERY Collaborative Group, Horby P, Lim WS, Emberson JR, Mafham M, Bell JL, et al. Dexamethasone in Hospitalized Patients with Covid-19. N Engl J Med. 2021; 384(8):693-704.

COVID-19 Treatment Guidelines: NIH [cited 2021 May 21]. Available from: https://www.covid19treatmentguidelines.nih.gov/immunomodulators/interleukin-6-inhibitors/

REMAP-CAP Investigators, Gordon AC, Mouncey PR, Al-Beidh F, Rowan KM, Nichol AD, et al. Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19. N Engl J Med. 2021; 384(16):1491-1502.

RECOVERY Collaborative Group, Abani O, Abbas A, Abbas F, Abbas M, Abbasi S, et al. Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. Lancet. 2021; 397(10285):1637-1645.

Kalil AC, Patterson TF, Mehta AK, Tomashek KM, Wolfe CR, Ghazaryan V, et al. Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19. N Engl J Med. 2021; 384(9):795-807.

Cao Y, Wei J, Zou L, Jiang T, Wang G, Chen L, et al. Ruxolitinib in treatment of severe coronavirus disease 2019 (COVID-19): a multicenter, single-blind, randomized controlled trial. J Allergy Clin Immunol. 2020;146(1):137-146.

Tardif JC, Bouabdallaoui N, L’Allier PL, Gaudet D, Shah B, Pillinger MH, et al. Efficacy of Colchicine in Non-Hospitalized Patients with COVID-19. medRxiv preprint doi: https://doi.org/10.1101/2021.01.26.21250494.

Rosen DA, Seki SM, Fernández-Castañeda A, Beiter RM, Eccles JD, Woodfolk JA, et al. Modulation of the sigma-1 receptor–IRE1 pathway is beneficial in preclinical models of inflammation and sepsis. Sci Transl Med. 2019; 11(478):eaau5266.

Lenze EJ, Mattar C, Zorumski CF, Stevens A, Schweiger J, Nicol GE, et al. Fluvoxamine vs placebo and clinical deterioration in outpatients with symptomatic COVID-19: a randomized clinical trial. JAMA. 2020; 324(22):2292-2300.

Robinson PC, Duncan Richards D, Helen L Tanner HL, Feldmann M. Accumulating evidence suggests anti-TNF therapy needs to be given trial priority in COVID-19 treatment. Lancet Rheumatol. 2020; 2(11):e653-e655.

Brenner EJ, Ungaro RC, Gearry RB, Kaplan GG, Kissous-Hunt K, Lewis JD, et al. Corticosteroids, but not TNF antagonists, are associated with adverse COVID-19 outcomes in patients with inflammatory bowel diseases: results from an international registry. Gastroenterology. 2020; 159 (91.e3): 481.

Veenith T, Fisher BA, Slade D, Rowe A, Sharpe R, David R. CATALYST trial protocol: a multicentre, open-label, phase II, multi-arm trial for an early and accelerated evaluation of the potential treatments for COVID-19 in hospitalised adults (preprint) medRxiv preprint doi: https://doi.org/10.1101/2021.02.10.21251478.

Downloads

Published

2021-08-01

How to Cite

1.
Theerawit P. Anti-inflammatory agents other than corticosteroid in SARs-CoV-2 pneumonia. Clin Crit Care [Internet]. 2021 Aug. 1 [cited 2024 Jun. 21];29:2021:e0001. Available from: https://he02.tci-thaijo.org/index.php/ccc/article/view/252686

Issue

Section

Short Review