Prognostic value of near-infrared spectroscopy in mortality and organ dysfunction in patients recovery from septic shock: The research protocol

Authors

  • Gunthiga Laplertsakul Division of Critical Care Medicine, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • Pongdhep Theerawit Division of Critical Care Medicine, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • Yuda Sutherasan Division of Pulmonary and Pulmonary Critical Care Medicine, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University,Bangkok, Thailand
  • Detajin Junhasavasdikul Division of Pulmonary and Pulmonary Critical Care Medicine, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University,Bangkok, Thailand

DOI:

https://doi.org/10.54205/ccc.v30.254767

Keywords:

Recovered from septic shock, Near-infrared spectroscopy

Abstract

Background: Sepsis or septic shock results in the alteration of blood flow at the microcirculatory level, affecting tissue oxygenation and organ function and associated with death. This study aimed to use near-infrared spectroscopy (NIRS) in conjunction with vascular occlusion test (VOT) to assess the association of microcirculatory dysfunction after recovered from septic shock and in-hospital mortality.

Methods: We conducted a prospective observational study in patients who recovered from septic shock. We performed NIRS with VOT within 24 hours of hospitalization in medical and anesthetic ICU (T0), then at the time of recovery from septic shock (D0), at day 3 (D3), day 5 (D5), and day 7 (D7) after recovery from septic shock. We recorded the de-oxygenation (DeO2) slope, the re-oxygenation (ReO2) slope, and the area under the hyperemic response curve (the reperfusion area). We focused on parameters of microcirculation dysfunction, in-hospital mortality, and in-hospital complications.

Hypothesis: We hypothesize that NIRS with vascular occlusion test parameters are associated with in-hospital mortality and hospital complications

Ethic: The study protocol has been approved by the Institution Review Board of Ramathibodi Hospital, Mahidol University, Thailand (No. MURA2020/147).

Trial registration: TCTR20220413001

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Published

2022-05-13

How to Cite

1.
Laplertsakul G, Theerawit P, Sutherasan Y, Junhasavasdikul D. Prognostic value of near-infrared spectroscopy in mortality and organ dysfunction in patients recovery from septic shock: The research protocol. Clin Crit Care [Internet]. 2022 May 13 [cited 2024 Jun. 16];30:2022:e0008. Available from: https://he02.tci-thaijo.org/index.php/ccc/article/view/254767

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Section

Research Protocol