Treatment of adults with severe dengue in Thailand.


  • Chaisith Sivakorn Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
  • Marcus J. Schultz Mahidol–Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
  • David Mabey London School of Hygiene and Tropical Medicine, UK
  • Samuel Clark Intensive Care Unit, NHS Foundation Trust, London, University College London Hospitals, UK
  • Adisorn Wongsa Division of Pulmonary and Critical Care, Department of Medicine, Phramongkutklao Hospital, Bangkok, Thailand
  • Nattachai Srisawat Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand



Treatment, Adult, Severe dengue, Dengue shock, Thailand


Key measures for improving the survival rate in dengue shock patients are an early and appropriate diagnosis and treatment together with close monitoring by early provision of appropriate types, rates, objectives, and limits (TROLs) of fluid therapies, especially in the critical phase of the disease. The hemodynamic assessments to guide fluid resuscitation should mainly rely on clinical signs, hematocrit along with non-invasive monitoring tools. These concepts aim to maintain adequate oxygen delivery to the vital organs, to prevent a prolonged shock stage and subsequent organ failures. Diagnosis and treatment for poor tissue perfusion should be initiated as early as possible from the onset of the cytokine cascade-induced plasma leakage and disruption of the glycocalyx layer of the vascular endothelial cells.


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Author Biographies

Chaisith Sivakorn, Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

Intensive Care Unit, NHS Foundation Trust, London, University College London Hospitals, UK

Marcus J. Schultz, Mahidol–Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

Department of Intensive Care & Laboratory of Experimental Intensive Care and Anesthesiology (L·E·I·C·A), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Oxford University, Oxford, UK.


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How to Cite

Sivakorn C, Schultz MJ, Mabey D, Clark S, Wongsa A, Srisawat N. Treatment of adults with severe dengue in Thailand. Clin Crit Care [Internet]. 2022 Apr. 13 [cited 2023 Mar. 26];30:2022:e0005. Available from:



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