An importance of respiratory drive and effort during mechanical ventilation

Respiratory drive and effort in respiratory failure


  • Pongdhep Theerawit Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, 10400
  • Phruet Soipetkasem Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, 10400



Respiratory drive, Respiratory effort, Asynchrony, P-SILI, ARDS


During mechanical ventilation, minimizing respiratory drive and effort becomes routine to prevent patient-ventilator asynchrony (PVA). As we know, PAV associates with poor outcomes in ICU patients. As a result, prescribing sedative drugs in combination with neuro-muscular blocking agents commonly appears in many ICUs. However, many patients develop adverse events from unloading respiratory muscles, resulting in prolonged mechanical ventilator and bad clinical outcomes. This review describes both sides of the adverse effect of respiratory drive and effort and tries to suggest the optimum point, believing that it may be associated with better outcomes.


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How to Cite

Theerawit P, Soipetkasem P. An importance of respiratory drive and effort during mechanical ventilation: Respiratory drive and effort in respiratory failure . Clin Crit Care [Internet]. 2023 Jan. 13 [cited 2023 Mar. 26];31(1):2023:e0001. Available from:



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