Comparison of guiding sedation level by respiratory effort versus usual care in mechanically ventilated patients: A randomized controlled trial protocol
The effect of sedation protocol guided by respiratory effort
DOI:
https://doi.org/10.54205/ccc.v32.268690Keywords:
Respiratory effort, Acute respiratory distress syndrome, Dynamic transpulmonary driving pressure swing, Sedation protocolAbstract
Background: Critically ill patients relying on mechanical ventilation often require excessive sedation, aiming to address asynchrony and prevent ventilator-induced lung injury (VILI). Unintentionally, there may be more suppression of respiratory efforts. It is well-established that improper respiratory efforts during mechanical ventilation can cause unfavorable outcomes.
Methods: Researchers conducted a single-center randomized control trial, parallel 2 groups (1:1 ratio), with 164 participants. One intervention group employed the optimal respiratory effort (predicted ΔPL, P0.1), and the other control group, employed usual care to guide the adjustment of sedative levels.
Hypothesis: To compare 28-day ventilator-free day (VFD) and mortality between measuring respiratory effort as opposed to usual care and adjusting sedative level during mechanical ventilation.
Conclusions: This study will evaluate the disparity in 28-day VFD and mortality between sedative level guidance by respiratory effort and usual care.
Ethics and dissemination: The study protocol received approval from the Human Research Ethics Committee, Faculty of Medicine Ramathibodi Hospital, Mahidol University (COA No. MURA2023/642)
Trial registration: NCT06242236
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