Management of critically ill obstetric patients

Management of critically ill obstetric patients

Authors

  • Touchapong Taksinwarajarn Division of Critical Care Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, 10400
  • Tananchai Petnak Division of Pulmonary and Pulmonary Critical Care Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, 10400

DOI:

https://doi.org/10.54205/ccc.v33.273471

Keywords:

Critical care in pregnancy, ICU, Pregnancy complications

Abstract

Pregnant patients requiring intensive care management present unique challenges due to physiological adaptations and pregnancy-specific conditions. While many aspects of critical care remain similar to non-pregnant patients, modifications in fluid resuscitation, medication selection, ventilatory support, and anticoagulation strategies are important to balance maternal stabilization with fetal safety. A multidisciplinary team approach, including obstetricians, intensivists, anesthesiologists, and neonatologists, is necessary for the effective management of critically ill pregnant patients. This review outlines key considerations in the critical care of pregnant patients, including hemodynamic, respiratory, and airway management, as well as sedation, thromboprophylaxis, and nutritional support. Additionally, pregnancy-related complications such as preeclampsia, pulmonary embolism, amniotic fluid embolism, and air embolism require specialized diagnostic and therapeutic approaches to ensure optimal maternal and fetal outcomes.

References

Ellegård EK. Clinical and pathogenetic characteristics of pregnancy rhinitis. Clinical reviews in allergy & immunology. 2004;26:149-59.

Miller T, Mueller T. Physiological changes during pregnancy. Obstetric Anesthesia Practice. 2021:1.

Cugell DW, Frank NR, Gaensler EA, Badger TL. Pulmonary function in pregnancy, I. Serial observations in normal women. American Review of tuberculosis. 1953;67:568-97.

ARCHER JR GW, MARX GF. Arterial oxygen tension during apnoea in parturient women. British Journal of Anaesthesia. 1974;46:358-60.

Hegewald MJ, Crapo RO. Respiratory physiology in pregnancy. clinics in chest medicine. 2011;32:1-13.

Silver HM, Seebeck M, Carlson R. Comparison of total blood volume in normal, preeclamptic, and nonproteinuric gestational hypertensive pregnancy by simultaneous measurement of red blood cell and plasma volumes. American journal of obstetrics and gynecology. 1998;179:87-93.

Mabie WC, DiSessa TG, Crocker LG, Sibai BM, Arheart KL. A longitudinal study of cardiac output in normal human pregnancy. American journal of obstetrics and gynecology. 1994;170:849-56.

Hughes SC, Levinson G, Rosen MA, Shnider SM. Shnider and Levinson's anesthesia for obstetrics: Lippincott Williams & Wilkins; 2002.

Crapo RO. Normal cardiopulmonary physiology during pregnancy. Clinical obstetrics and gynecology. 1996;39:3-16.

Baylis C. Glomerular filtration rate in normal and abnormal pregnancies. In: Seminars in nephrology: 1999, pp 133-9.

Chesnutt AN. Physiology of normal pregnancy. Critical care clinics. 2004;20:609-15.

Ahonen J, Stefanovic V, Lassila R. Management of post‐partum haemorrhage. Acta anaesthesiologica scandinavica. 2010;54:1164-78.

Konstantinides SV, Meyer G, Becattini C, Bueno H, Geersing G-J, Harjola V-P, et al. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS) The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC). European heart journal. 2020;41:543-603.

Zieleskiewicz L, Chantry A, Duclos G, Bourgoin A, Mignon A, Deneux-Tharaux C, et al. Intensive care and pregnancy: epidemiology and general principles of management of obstetrics ICU patients during pregnancy. Anaesthesia Critical Care & Pain Medicine. 2016;35:S51-S7.

Muller L, Bobbia X, Toumi M, Louart G, Molinari N, Ragonnet B, et al. Respiratory variations of inferior vena cava diameter to predict fluid responsiveness in spontaneously breathing patients with acute circulatory failure: need for a cautious use. Critical Care. 2012;16:1-7.

Brun C, Zieleskiewicz L, Textoris J, Muller L, Bellefleur J-P, Antonini F, et al. Prediction of fluid responsiveness in severe preeclamptic patients with oliguria. Intensive Care Medicine. 2013;39:593-600.

Muench MV, Canterino JC. Trauma in pregnancy. Obstetrics and gynecology clinics of North America. 2007;34:555-83.

Allred CC, Esquinas AM, Caronia J, Mahdavi R, Mina BA. Successful use of noninvasive ventilation in pregnancy. European Respiratory Review. 2014;23:142-4.

Cole DE, Taylor TL, McCullough DM, Shoff CT, Derdak S. Acute respiratory distress syndrome in pregnancy. Critical care medicine. 2005;33:S269-S78.

Talmor D, Sarge T, Malhotra A, O'Donnell CR, Ritz R, Lisbon A, et al. Mechanical ventilation guided by esophageal pressure in acute lung injury. New England Journal of Medicine. 2008;359:2095-104.

Kenn S, Weber-Carstens S, Weizsaecker K, Bercker S. Prone positioning for ARDS following blunt chest trauma in late pregnancy. International journal of obstetric anesthesia. 2009;18:268-71.

Nair P, Davies AR, Beca J, Bellomo R, Ellwood D, Forrest P, et al. Extracorporeal membrane oxygenation for severe ARDS in pregnant and postpartum women during the 2009 H1N1 pandemic. Intensive care medicine. 2011;37:648-54.

Esmaoglu A, Ulgey A, Akin A, Boyaci A. Comparison between dexmedetomidine and midazolam for sedation of eclampsia patients in the intensive care unit. Journal of critical care. 2009;24:551-5.

Iqbal MM, Sobhan T, Ryals T. Effects of commonly used benzodiazepines on the fetus, the neonate, and the nursing infant. Psychiatric Services. 2002;53:39-49.

Gaffney A. Critical care in pregnancy—Is it different? In: Seminars in perinatology, Elsevier. 2014, pp 329-40.

Middleton P, Shepherd E, Gomersall JC. Venous thromboembolism prophylaxis for women at risk during pregnancy and the early postnatal period. Cochrane Database of Systematic Reviews. 2021.

Singer P, Blaser AR, Berger MM, Calder PC, Casaer M, Hiesmayr M, et al. ESPEN practical and partially revised guideline: clinical nutrition in the intensive care unit. Clinical Nutrition. 2023;42:1671-89.

McDonnell N. Cardiopulmonary arrest in pregnancy: two case reports of successful outcomes in association with perimortem Caesarean delivery. British Journal of Anaesthesia. 2009;103:406-9.

Lindheimer MD, Taler SJ, Cunningham FG. ASH position article. Hypertension in pregnancy. J Am Soc Hypertens. 2008;2:484-94.

Magee LA, Nicolaides KH, von Dadelszen P. Preeclampsia. N Engl J Med. 2022;386:1817-32.

Preeclampsia A. Gestational hypertension and preeclampsia: ACOG practice bulletin, Number 222. Obstet Gynecol. 2020;135:e237-e60.

Weinstein L. Syndrome of hemolysis, elevated liver enzymes, and low platelet count: a severe consequence of hypertension in pregnancy. American journal of obstetrics and gynecology. 1982;142:159-67.

Obstetricians RCo, Gynaecologists. Reducing the risk of venous thromboembolism during pregnancy and the puerperium. Green Top Guideline. 2015.

Bates SM, Greer IA, Middeldorp S, Veenstra DL, Prabulos A-M, Vandvik PO. VTE, thrombophilia, antithrombotic therapy, and pregnancy: antithrombotic therapy and prevention of thrombosis: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012;141:e691S-e736S.

Kher A, Bauersachs R, Nielsen JD. The management of thrombosis in pregnancy: role of low-molecular-weight heparin. Thrombosis and haemostasis. 2007;97:505-13.

Cohen H, Arachchillage D, Middeldorp S, Beyer‐Westendorf J, Abdul‐Kadir R. Management of direct oral anticoagulants in women of childbearing potential: guidance from the SSC of the ISTH. Journal of Thrombosis and Haemostasis. 2016;14:1673-6.

Knight M, Berg C, Brocklehurst P, Kramer M, Lewis G, Oats J, et al. Amniotic fluid embolism incidence, risk factors and outcomes: a review and recommendations. BMC pregnancy and childbirth. 2012;12:1-11.

Benson MD, Kobayashi H, Silver RK, Oi H, Greenberger PA, Terao T. Immunologic studies in presumed amniotic fluid embolism. Obstetrics & Gynecology. 2001;97:510-4.

Pacheco LD, Saade G, Hankins GD, Clark SL, Medicine SfM-F. Amniotic fluid embolism: diagnosis and management. American journal of obstetrics and gynecology. 2016;215:B16-B24.

Viau-Lapointe J, Filewod N. Extracorporeal therapies for amniotic fluid embolism. Obstetrics & Gynecology. 2019;134:989-94.

OREBAUGH SL. Venous air embolism: clinical and experimental considerations. Critical care medicine. 1992;20:1169-77.

Bach AG, Restrepo CS, Abbas J, Villanueva A, Dus MJL, Schöpf R, et al. Imaging of nonthrombotic pulmonary embolism: biological materials, nonbiological materials, and foreign bodies. European journal of radiology. 2013;82:e120-e41.

Malik N, Claus PL, Illman JE, Kligerman SJ, Moynagh MR, Levin DL, et al. Air embolism: diagnosis and management. Future Cardiology. 2017;13:365-78.

Burlinson C, Sirounis D, Walley K, Chau A. Sepsis in pregnancy and the puerperium. International journal of obstetric anesthesia. 2018;36:96-107.

Berkowitz K, LaSala A. Risk factors associated with the increasing prevalence of pneumonia during pregnancy. American journal of obstetrics and gynecology. 1990;163:981-5.

Bowyer L, Robinson HL, Barrett H, Crozier TM, Giles M, Idel I, et al. SOMANZ guidelines for the investigation and management sepsis in pregnancy. Australian and New Zealand Journal of Obstetrics and Gynaecology. 2017;57:540-51.

Trikha A, Singh PM. Management of major obstetric haemorrhage. Indian journal of anaesthesia. 2018;62:698-703.

Shevell T, Malone FD. Management of obstetric hemorrhage. In: Seminars in perinatology, Elsevier. 2003, pp 86-104.

Segal S, Shemesh I, Blumenthal R, Yoffe B, Laufer N, Ezra Y, et al. Treatment of obstetric hemorrhage with recombinant activated factor VII (rFVIIa). Archives of gynecology and obstetrics. 2003;268:266-7.

Shakur H, Roberts I, Fawole B, Chaudhri R, El-Sheikh M, Akintan A, et al. Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial. The Lancet. 2017;389:2105-16.

Sentilhes L, Winer N, Azria E, Sénat M-V, Le Ray C, Vardon D, et al. Tranexamic acid for the prevention of blood loss after vaginal delivery. New England Journal of Medicine. 2018;379:731-42.

Downloads

Published

2025-03-28

How to Cite

1.
Taksinwarajarn T, Petnak T. Management of critically ill obstetric patients: Management of critically ill obstetric patients. Clin Crit Care [internet]. 2025 Mar. 28 [cited 2025 Apr. 21];33(1):e250009. available from: https://he02.tci-thaijo.org/index.php/ccc/article/view/273471

Issue

Section

Review Articles