The Safety, Tolerability, and Efficacy of Once-Daily Generic Memantine Hydrochloride Produced in Thailand: A Multicenter, Naturalistic Study in Dementia

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Published: Mar 30, 2015
Keywords:
Memantine Efficacy Tolerability Naturalistic Dementia Generic Thailand

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Ronnachai Kongsakon
Department of Psychiatry, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Oraluck Pattanaprateep
Section for Clinical Epidemiology and Biostatistics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

Abstract

Memantine has been approved in Thailand for moderate-to-severe dementia. This study aimed to evaluate the efficacy, safety, and tolerability of the generic memantine hydrochloride manufactured in Thailand in Thai dementia patients. Sixty patients from 9 centers at outpatient unit with moderate to severe dementia were received 10-20 mg the study drug one-daily for 12 weeks. Safety and tolerability were assessed through the adverse event questionnaires. Of the 60 patients who completed the study, the endpoint clinical global impression (CGI) scores were statistically significant decreased from the baseline (4.80 + 1.34 vs. 3.10 + 0.90). The common adverse events observed in this study were headache (6.6%), diarrhea (6.6%) and nausea/vomiting (5%). Inconclusion, the generic memantine used in this study was efficacious, safe, and well tolerated in Thai dementia patients. 

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1.
Kongsakon R, Pattanaprateep O. The Safety, Tolerability, and Efficacy of Once-Daily Generic Memantine Hydrochloride Produced in Thailand: A Multicenter, Naturalistic Study in Dementia. Rama Med J [Internet]. 2015 Mar. 30 [cited 2024 Apr. 23];38(1):40-7. Available from: https://he02.tci-thaijo.org/index.php/ramajournal/article/view/95201
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Vol. 38 No. 1 (2015): January-March
Section
Original Articles

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