TY - JOUR AU - Krittayot Patchanee, M.D., AU - Nilnetre Mahathanaruk, M.D., AU - Phurich Praneetvatakul, M.D., PY - 2023/01/27 Y2 - 2024/03/29 TI - External Validation of Risk Scores for Clinically Significant Hypocalcemia in Patients Underwent Total Thyroidectomy, A Retrospective Study JF - Thai Journal of Otolaryngology Head and Neck Surgery JA - rcotJ VL - 23 IS - 2 SE - Reseach Articles DO - UR - https://he02.tci-thaijo.org/index.php/rcotJ/article/view/259922 SP - AB - <p>Abstract</p><p>Introduction<br />Hypocalcemia is among the most common post-operative total thyroidectomy complications. There are <br />established risk factors predicting risk of hypocalcemia in patients underwent total thyroidectomy. <br />However, there is no single factor with high predictive power for post-operative hypocalcemia or <br />factors which predict hypocalcemia before surgery. There are several risk scores published but not <br />widely acceptable and there is no study externally validate those scores. Risk scores by Pradeep¹ <br />and Papanastasiou (CaReBe’S TiP Score)² were externally validated using database of Faculty of <br />Medicine Ramathibodi Hospital.</p><p><br />Objective<br />To externally validate risk scores by Pradeep¹ and Papanastasiou² and find their predictive powers</p><p><br />Study design<br />A retrospective database of patients underwent total thyroidectomy during 2017-2021 were<br />obtained. Sensitivity, specificity, odds ratio were calculated from 2 risk scores.</p><p>Results:<br />CaReBe’s Tip score from 3 and above has sensitivity and specificity 81.21% and 63.79%. For the <br />score 4 and above, sensitivity and specificity is 18.18 and 93.10. Area under ROC is 0.754. Post- <br />operative PTH level is the only factor that associated with 24-hr post-operative hypocalcemia and <br />clinically significant hypocalcemia for both scores. Due to limitation of data, predictive power of <br />Pradeep’s score cannot be calculated. Number of preserved parathyroid gland of less than and equal <br />to 2 glands significantly predicts permanent hypoparathyroidism.</p><p><br />Conclusion:<br />Post-operative PTH level below 14.9 pg/mL is a strong predictor for post-operative hypocalcemia.</p><p><br />Keywords: total thyroidectomy, hypocalcemia, risk score</p> ER -