Original Article SMJ
Effect of Diabetes
A Randomized Controlled Trial
Ornsuda Lertbannaphong, M.D.*, Pimonsri Hantanasiriskul, M.D.*, Pornpimol Kiattisakthavee, M.D.*, Sunsanee Ruangson, M.D.**, Nantawat Sitdhiraksa M.D.***, Jeerunda Santiprabhob, M.D.*,****
*Division of Endocrinology and Metabolism, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand, **Department of Pediatrics, Nakhonpathom Hospital, Nakhonpathom 73000, Thailand, ***Department of Psychiatry, ****Siriraj Diabetes Center of Excellence, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
ABSTRACT
Objective: Type 1 diabetes mellitus (T1DM) is a chronic disease that is difficult to control. Motivational interviewing (MI) is a collaborative style of communication that was designed to strengthen a person’s motivation and commitment to change and improve. We hypothesized that applying MI to diabetes care would lead to improved glycemic control and improved diabetes
Materials and Methods: Subjects were T1DM patients aged
Results: |
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1C |
different between groups. At the end of the study, |
HbA1C levels were not significantly different within or between |
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groups. From |
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and medical taking. Transition to the |
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stages of change action stage was increased from 0 to 12 persons. |
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Conclusion: The effectiveness of MI on glycemic |
control was not found to |
be statistically significant at 6 months. |
However, continuation of DSME in T1DM patients is necessary for improving diabetes knowledge and care. Further study in a larger sample size with longer duration of MI and
Keywords: T1DM; motivational interviewing diabetes;
J 2021; 73:
Corresponding author: Jeerunda Santiprabhob
Received 8 July 2021 Revised 30 July 2021 Accepted 2 August 2021
ORCID ID:
http://dx.doi.org/10.33192/Smj.2021.82
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Lertbannaphong et al.
INTRODUCTION
Type 1 diabetes mellitus (T1DM) is a complex and chronic disease that requires lifelong insulin injections, psychological support, and lifestyle changes. To optimize glycemic control, regular and frequent self- monitoring of blood glucose (SMBG) is required. Ziegler R, et al. found one additional SMBG per day to be associated with a decrease in HbA1c of 0.20%.1 Miller KM, el al. also found a higher number of SMBGs per day to be strongly associated with a lower HbA1c level.2 The numbers of SMBGs per day in the patients at our outpatient clinic3 was
Another factor in addition to SMBG that contributes to good glycemic control is motivation. Motivational interviewing (MI), which was developed by Miller WR. and Rollnick S., is a proven approach for working through ambivalence and facilitating change of behavior.5 MI has been widely used in adults to improve control of addictive behaviors, such as reducing illicit drug use6 and promoting smoking cessation.7,8 During the last decade, MI has been used in pediatric practice to promote adherence to recommended treatment, including diabetes management with variable results in reducing
MI is a brief,
the patient relapse, which is defined as a return to any of the previous behavior stages12
Thus we conducted a
MATERIALS AND METHODS
Design and participants
Following randomization, participants received either diabetes
Randomization was generated by random permuted blocks with mixed block size. Group allocation results were sealed in sequentially numbered opaque envelopes. The person generated the allocation scheme had no additional role in the study. The protocol for this randomized controlled trial was approved by the Siriraj Institutional Review Board (SIRB) of the Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand (COA no. Si 538/2016). Assent and written informed consent was obtained from patients and their parents/guardians, respectively.
The frequency of SMBG was assessed by downloading glucometer data using
636 Volume 73, No.10: 2021 Siriraj Medical Journal |
Original Article SMJ
Motivational interviewing (MI)
MI sessions were conducted by 3 interventionists, including 2 pediatric endocrinologists and a pediatric endocrinology fellow) and a diabetes education nurse. All interventionists were trained by experienced pediatric and adult psychiatrists from Department of Pediatrics and Department of Psychiatry, Faculty of Medicine Siriraj Hospital, Mahidol University. The initial training in MI includes hours of lecture, role play, case scenarios, and practicing with actual patients in individual and group sessions. Monthly discussion and supervision among interventionists and a psychiatrist was continued throughout the study.
MI in group session was performed at the beginning of the study, and at 3 months after entering the study. The length of the two MI sessions was
Diabetes
beginning of the study, and 3 months later in both the DSME and DSME plus MI groups. The session was designed as an interactive lecture and workshop, with a length of
facts. Food models were used for food exchange and nutrition fact practice. Patients were encouraged to participate in class by asking questions, giving examples, and using case scenarios. We also focused on individual
Diabetes knowledge test
Diabetes knowledge test was performed at the beginning and end of the study. We modified a multiple choice test using 30 questions from the diabetes knowledge test administered at the Siriraj Diabetes Camp.13 Questions covered 7 topics, including basic diabetes knowledge, nutritional management and carbohydrate counting,
Diabetes
at the beginning and the end of the study. A
Statistical analysis
All data analyses were performed using SPSS Statistics (SPSS, Inc., Chicago, IL, USA). Patient characteristics were summarized using descriptive statistics. Categorical data were compared using chi- square test, and the results are presented as frequency or percentage. Normally distributed continuous data was compared using independent
RESULTS
A flow diagram of the study protocol is shown in Fig 1. Of the 94 patients who received free glucose strips from the UC program, 39 were eligible for this study. Those patients were randomized into either the DSME
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Lertbannaphong et al.
Eligible patients (n=94)
Excluded (n=55)
- not meeting inclusion criteria (n=54)
- received drug affected glycemic control (n=1)
Randomized (n=39)
DSME (n=20)
-lost to follow up (n=1)
-switching insulin regimen (n=2)
At 3 months (n=17)
DSME with MI (n=19)
- drop out (n=1)
At 3 months (n=18)
At 6 months (n=17)
At 6 months (n=18)
Fig 1. Flow diagram of the study protocol.
group (n=20) or the DSME plus MI group (n=19). One patient in DSME group was lost to
Demographic characteristics
Patients in the DSME and DSME plus MI groups were well matched for age (14.18±2.02 vs. 14.06±2.88 years, respectively), age at diagnosis (8.25±2.86 vs. 8.53±3.83 years), duration of diabetes [5.25 (0.83, 13.33) vs. 5.08 (1, 14) years], and HbA1c [10.3% (8.4, 14) vs. 9.45% (8, 14.6)]. There were no significant differences between groups for age, age at diagnosis, duration of diabetes, or HbA1c, as shown in Table 1. Counting carbohydrate in grams was 30% and 22%; using basal
bolus regimen was 58% and 38% in the DSME and DSME plus MI groups respectively.
Primary outcome: HbA1C
Baseline HbA1C in the DSME and DSME plus MI groups was 10.3 (8.4, 14) and 9.45 (8, 14.6), respectively (p=0.204). At the end of the study, HbA1C in the DSME and DSME plus MI groups was 9.8 (7.4, 16.8) and 9.35 (7.8, 13.2), respectively (p=0.234). No significant difference was observed for HbA1C in each group compared between
Diabetes knowledge score
Diabetes knowledge score compared between baseline and 6 months increased significantly in both the DSME and DSME plus MI groups [19 (7, 24) to 21 (6, 25); p=0.012, and 18.5 (13, 24) to 21 (15, 28); p=0.001 respectively] (Table 3).
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Original Article SMJ
TABLE 1. Baseline characteristics.
|
DSME |
DSME + MI (n=18) |
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(n=17) |
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Age* (years) |
14.18 ± 2.02 |
14.06 ± 2.88 |
0.892 |
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|
Age at diagnosis* (years) |
8.25 |
± 2.86 |
8.53 |
± 3.83 |
0.810 |
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BMI * (kg/m2) |
20.70 ± 3.70 |
20.66 ± 3.04 |
0.971 |
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Total daily dose* (units/day) |
1.26 |
± 0.33 |
1.25 |
± 0.35 |
0.934 |
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|
Duration of DM**(years) |
5.25 |
(0.83, 13.33) |
5.08 |
(1, 14) |
0.766 |
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|
SMBG** (times/day) |
2.00 |
(0.1, 4) |
3.2 (0.07, 4.9) |
0.013 |
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|
|
HbA1C** (%) |
10.3 |
(8.4, 14) |
9.45 |
(8, 14.6) |
0.204 |
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|
Gender# male/female |
10/7 |
|
9/9 |
|
0.600 |
Insulin regimen# basal |
10/7 |
|
7/11 |
|
0.472 |
Carbohydrate counting# grams/portion |
5/12 |
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4/14 |
|
0.627 |
Lipohypertrophy# yes/no |
6/11 |
|
6/12 |
|
0.903 |
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Diabetic nephropathy# yes/no |
1/16 |
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1/17 |
|
0.967 |
Diabetic retinopathy# yes/no |
17/0 |
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17/1 |
|
0.324 |
Hypertension# yes/no |
0/17 |
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0/18 |
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- |
Dyslipidemia# yes/no |
8/9 |
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13/5 |
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0.129 |
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* Independent
Abbreviations: DSME, diabetes
TABLE 2. HbA1c levels compared between groups at baseline, 3 months, and 6 months.
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DSME |
DSME + MI (n=18) |
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(n=17) |
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HbA1c |
at baseline |
10.3 |
(8.4, 14) |
9.45 |
(8, 14.6) |
0.204 |
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|
HbA1c |
at 3 months |
10.1 |
(7.4, 17.6) |
9.35 |
(7.8, 14.5) |
0.095 |
HbA1c |
at 6 months |
9.8 (7.4, 16.8) |
9.35 |
(7.8, 13.2) |
0.234 |
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0.813 |
0.459 |
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*Compared between DSME and DSME + MI, **Compared between
Abbreviations: DSME, diabetes
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Lertbannaphong et al.
TABLE 3. Pretest and
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DSME |
DSME + MI |
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(N=17) |
(N=18) |
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Pretest score |
19 (7, 24) |
18.5 (13, 24) |
0.816 |
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21 (6, 25) |
21 (15, 28) |
0.326 |
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0.012 |
0.001 |
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*Compared between DSME and DSME + MI, **Compared between
Abbreviations: DSME, diabetes
The
problem solving, stress management, or reducing risk of diabetes complications domains.
Stage of MI
In DSME plus MI group, at the beginning of the study, there was 1 patient in
TABLE 4.
Topics |
DSME |
DSME + MI |
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(% of mean) |
(% of mean) |
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Personal hygiene care |
71.43 |
69.04 |
0.765 |
|
(28.57, 100) |
(33.33, 100) |
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Dietary control |
48.97 |
60.20 |
0.024 |
|
(32.65, 73.47) |
(30.61, 77.55) |
|
Medication taking |
52.38 |
67.86 |
0.016 |
|
(28.57, 78.57) |
(47.62, 80.95) |
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Physical activity |
57.14 |
64.29 |
0.337 |
|
(19.05, 90.48) |
(9.52, 85.71) |
|
39.29 |
51.79 |
0.068 |
|
|
(17.86 , 78.57) |
(28.57 , 67.86) |
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Problem solving |
48.21 |
50.89 |
0.895 |
|
(23.21, 78.57) |
(30.36, 71.43) |
|
Stress management |
47.62 |
40.47 |
0.640 |
|
(0, 71.43) |
(0, 71.43) |
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Reducing risk of diabetes complications |
57.14 |
55.36 |
0.973 |
|
(35.71, 71.43) |
(35.71, 71.43) |
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Data expressed as median (min, max)
Abbreviations: DSME, diabetes
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Original Article SMJ
TABLE 5. Stages of change in the motivational interviewing group (n=18).
Stage of Change |
Sessions (months) |
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0 |
1 |
2 |
3 |
4 |
5 |
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1 |
1 |
1 |
- |
- |
- |
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Contemplation |
8 |
6 |
5 |
2 |
- |
3 |
Determination |
9 |
6 |
3 |
15 |
6 |
3 |
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Action |
- |
5 |
9 |
1 |
12 |
12 |
Maintenance & |
- |
- |
- |
- |
- |
- |
relapse prevention |
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SMBG
Baseline SMBG frequency in the DSME and DSME plus MI groups was 2 (0.1, 4) and 3.2 (0.07, 4.9) times/day, respectively (p=0.013). At the end of the study, SMBG frequency in the DSME group and the DSME plus MI group was 2 (0, 4) and 3 (0, 4.7) times/day, respectively (p=0.053). SMBG frequency data was downloaded from the glucometer at baseline, 3- and
DISCUSSION
We found no significant different in HbA1C between the DSME and DSME plus MI groups at the end of the study, as well as between pre- and post- intervention. Diabetes knowledge score in both groups was significantly increased at the end of study.
T1DM is a complex and chronic illness that requires consistent adherence to treatment, psychological support, and changes in lifestyle. Optimal glycemic control is not easy to achieve, requires commitment to change, and depends on multiple factors. Accurate carbohydrate counting is crucial for precise insulin calculation. The DAFNE Study Group reported significant improvement in HbA1C at 6 months (p<0.0001) after training patients how to match their insulin dose to their food choice.15 As demonstrated by Spiegel G, et al., T1DM patients overestimated and underestimated carbohydrate content, especially in mixed meals.16 Moreover, less than half of our patients were counting carbohydrates as grams, not portions (Table 1). Calculating insulin dose according to carbohydrate portion size may yield a loser insulin dose than calculating according to gram
weight. This may result in a suboptimal dose of insulin and poor glycemic control. Intensive patient education in carbohydrate counting and encouraging patients to count carbohydrates accurately may result in accurate insulin calculation and improving of glycemic control.
At the end of the intervention, the patients in the DSME plus MI group did better in the dietary control and medicine taking domains of
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Lertbannaphong et al.
psychological issue might be another factor. The burden of having type 1 diabetes and the demands in managing daily
The duration of this study may have been too short to observe the effect of MI. In the present study, transition to the action stage of MI was observed at 4 months, so measurement of HbA1C at 6 months may be too early to observe the effect of action that recently took place. Channon S, et al. conducted a randomized controlled trial that showed significant reduction of HbA1C in the MI group compared to the control group at 12 months and 24 months, but not at 6 months.21 In our study, HbA1C was not significantly decreased in any comparison. On the other hand, MI may not affect glycemic control. Walter G. suggested that verbal indices of MI to change do not necessarily translate to actual change in response to treatment if the patient does not also have the ability to change, and that patient declarations should be regarded as reflecting the patient’s intent to change at that moment as opposed to being considered a predictor of real change in behavior.22
Diabetes knowledge score was significantly improved in both groups, which is similar to the finding reported by Santiprabhob, et al. at 6 months
The limitations of this study are short duration of intervention, infrequency of motivation intervention sessions and small sample size. Increasing the duration, intensity, and frequency of MI sessions, as well as focusing on individual ambivalence, may have positive impact on MI stage progression and actual change. It should also be considered that our small sample size may have given our study insufficient statistical power to identify all significant differences in HbA1C.
CONCLUSION
In conclusion, this study demonstrated that applying MI to diabetes care does not lead to improvement in glycemic control. However, diabetes knowledge was
improved in both groups, and
ACKNOWLEDGEMENTS
The authors wish to thank the T1DM patients and their families that participated in this study, Julaporn Pooliam and Kanokwan Sommai for statistical analysis, and Hathaichanok Tirapongporn and Sriwan Thongpang for nutritional teaching. This study was supported by a Siriraj Routine to Research Fund, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand (grant no. R015935055).
Conflict of interest: The authors hereby declare no personal or professional conflicts of interest relating to any aspect of this study.
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