@article{Vichianin_Kareesaw_Chawalparit_Ohki_2018, title={Optimizing Fractional Intensity Threshold for FSLBrain Extraction Tool (BET) and Comparing with FreeSurfer on 3D T1W MR Images}, volume={70}, url={https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/152639}, abstractNote={<p><strong>Objective</strong>: To find out the optimal Brain Extraction Tool (BET) parameter (fractional intensity threshold) for<br>measuring the brain volume compared with the standard manual method in our institute and to compare with<br>those of automated FreeSurfer software<br><strong>Methods</strong>: This retrospective study was performed in 10 healthy adult subjects with data of 3D-T1W on 3T MR<br>machine. The manual gold standard brain volume measurements were done by two independent readers. The<br>automated segmentations using BET with varied parameters and FreeSurfer software were also performed. Then,<br>the two automated methods were compared with the manual tracing to make the optimal parameter by seeking for<br>the highest intraclass correlation coefficient (ICC) using SPSS software.<br><strong>Results</strong>: The fractional intensity threshold for whole brain volume measurement of 0.1- 0.6 showed high ICC with<br>the manual gold standard (ranging from 0.639 to 0.748). The best value was 0.1, showing highest ICC of 0.748<br>(p < 0.006) with confidence interval of 95% equal to (0.242; 0.932). There were no optimal parameters for right and<br>left hippocampus volume measurement by BET due to very low ICC between BET and the reader (ICC ranging<br>from 0.017 to 0.139 and from 0.012 to 0.110, for the right and left hippocampus volume, respectively). The ICC<br>values of the automated FreeSurfer method with the manual tracing were also very low (0.063, 0.068, and 0.063 for<br>right, left and bilateral hippocampi respectively).<br><strong>Conclusion</strong>: The optimal BET parameter (fractional intensity threshold) for automated brain volume measurement<br>in our institute is 0.1 similar to the suggested value by prior study with high agreement (ICC=0.748) to the manual<br>method.</p>}, number={5}, journal={Siriraj Medical Journal}, author={Vichianin, Yudthaphon and Kareesaw, Adisorn and Chawalparit, Orasa and Ohki, Masafumi}, year={2018}, month={Oct.}, pages={391–396} }