@article{Booranapong_Prabhasawat_Chotikavanich_Tongsai_Naranunn_Thaweerattanasilp_Kosrirukvongs_2019, title={Comparison of an Automated Thermodynamic Treatment System (LipiFlow) and Warm Compresses for the Treatment of Moderate Severity of Meibomian Gland Dysfunction}, volume={72}, url={https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/228936}, DOI={10.33192/Smj.2020.11}, abstractNote={<p><strong>Objective: </strong>To compare the efficacies of a single thermodynamic treatment system (LipiFlow<sup>®</sup>) and warm compresses used for 3 months in patients with a moderate severity of meibomian gland dysfunction (MGD).    <br><strong>Methods: </strong>This prospective, randomized, controlled clinical study enrolled 28 patients (22 females, 6 males; mean age, 53.9 ± 14.8 years) diagnosed as having moderate MGD by plugging at the meibomian gland orifices between one-third and two-thirds of lid margins and at least one of the following: a Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire score of 6-12; <sup> </sup>a lipid layer thickness (LLT) score of 40-70 Interferometric Color Units; upper eyelid meiboscore of 1<strong>-</strong>2; and 3<strong>-</strong>6 expressible meibomian glands (EMGs) in the lower eyelid<strong>. </strong>Both eyes of each patient were randomized into study and control eyes. Study eyes were treated with a single, 12-minute LipiFlow<sup>® </sup>system, while control eyes received 5-minute warm compresses twice daily for 3 months. The dry eye symptoms, the number of EMGs, and LLTs were evaluated.<br><strong>Results:</strong> There were no significant differences in the dry eye symptoms, number of EMGs, and LLTs for both groups at baseline and at each follow-up. However, the total SPEED scores for the LipiFlow<sup>®</sup> group reduced significantly from baseline at each follow-up until 6 months. As to the warm compress group, the total SPEED scores reduced significantly from baseline at each follow-up until 3 months.<br><strong>Conclusion: </strong>The single LipiFlow<sup>®</sup> treatment and twice-daily warm compresses relieved the dry eye symptoms of patients with a moderate severity of MGD compared with their baseline symptoms, despite no statistical differences in the dry eye symptoms, number of EMGs, and LLTs of both treatments. </p>}, number={1}, journal={Siriraj Medical Journal}, author={Booranapong, Wipawee and Prabhasawat, Pinnita and Chotikavanich, Suksri and Tongsai, Sasima and Naranunn, Patsathorn and Thaweerattanasilp, Wilaipun and Kosrirukvongs, Panida}, year={2019}, month={Dec.}, pages={79–86} }