@article{Chularojanamontri_Silpa-archa_Chaweekulrat_Likitwattananurak_Weerasubpong_Junsuwan_Charoenpipatsin_Wongpraparut_2020, title={A Randomised Controlled Trial of the Efficacy and Safety of 0.25% Desoximetasone Cream (Topoxy) Compared with 0.25% Desoximetasone Cream (Topicorte) for the Treatment of Scalp Psoriasis}, volume={72}, url={https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/241932}, DOI={10.33192/Smj.2020.50}, abstractNote={<p><strong>Objective:</strong> To compare the efficacy and safety of a generic desoximetasone cream (Topoxy) with the reference form, Topicorte, for the treatment of scalp psoriasis.<strong><br>Methods: </strong>A randomised, double-blind, controlled study was conducted. Altogether, 105 patients with psoriasis lesions covering more than 10% of the scalp were randomised into three groups. The first, second and third groups received a placebo, Topoxy and Topicorte, respectively. The scalp psoriasis severities were assessed at weeks 0, 2, 4 and 8, using the Investigator Global Assessment (IGA) scale and Total Sign Score (TSS). The safety profiles of the products were assessed by the patients and physicians.<strong><br>Results: </strong>Topoxy and Topicorte were significantly more effective than the placebo in achieving at least a two-grade improvement in the IGA score from baseline at weeks 2, 4 and 8, and there were no significant differences between Topoxy and Topicorte. The TSS of both creams were significantly lower than that of the placebo at weeks 2, 4 and 8. All patients tolerated well to the therapy.<strong><br>Conclusion: </strong>Topoxy and Topicorte had comparable efficacies for scalp psoriasis., The medications were superior to the placebo in all parameters, and  had a good safety profile.</p>}, number={5}, journal={Siriraj Medical Journal}, author={Chularojanamontri, Leena and Silpa-archa, Narumol and Chaweekulrat, Pichanee and Likitwattananurak, Chayanee and Weerasubpong, Puncharas and Junsuwan, Natchaya and Charoenpipatsin, Norramon and Wongpraparut , Chanisada}, year={2020}, month={May}, pages={371–379} }