TY - JOUR AU - Harnphadungkit, Kamontip AU - Akarasereenont, Pravit AU - Chadvongvan, Pranee AU - Chotiyarnwong, Chayaporn PY - 2018/10/30 Y2 - 2024/03/29 TI - Efficacy of 0.0125% Capsaicin Patch at Acupuncture Point for Pain Relief in Knee Osteoarthritis: A Randomized Controlled Trial JF - Siriraj Medical Journal JA - Siriraj Med J VL - 70 IS - 5 SE - Original Article DO - UR - https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/152638 SP - 382-390 AB - <p><strong>Objective</strong>: To study the efficacy of 0.0125% capsaicin patch at acupuncture point for pain relief in knee osteoarthritis (OA).<br><strong>Methods</strong>: This randomized, double-blind, placebo-controlled clinical trial was conducted during September 2014<br>to March 2015. Sixty-two ambulatory patients over 50 years of age with a diagnosis of knee OA were included. All<br>enrolled patients had a pain score of 4-7 out of 10. Participants were randomized into either the treatment (capsaicin,<br>n=31) or control (placebo, n=31) group.<br><strong>Interventions</strong>: Capsaicin vs. placebo patch at ST34 (1), SP10 (2), ST35 (3), EX-LE4 (Neixiyan) (4), ST36 (5), and<br>SP9 (6) acupuncture points for 4 weeks. Main outcome measure: Pain subscale of modified Thai version of Western<br>Ontario and McMaster (WOMAC) Osteoarthritis Index was assessed at baseline, 2, 4, 6, and 8 weeks after treatment.<br><strong>Results</strong>: Pain subscale of modified Thai version of WOMAC showed no significant difference between groups at<br>baseline, 2, 4, 6, and 8 weeks after treatment. After 2 weeks of treatment, the pain subscale score in the treatment<br>group was significantly decreased from baseline (p&lt;0.001). After 4 weeks of treatment, the pain subscale score in<br>the placebo group was significantly decreased from baseline (p&lt;0.006).<br><strong>Conclusion</strong>: Capsaicin patch at acupuncture point for pain relief in knee OA yielded no significant difference<br>between groups. However, significant pain relief from baseline was observed in the treatment group after 2 weeks<br>of treatment and in the placebo group after 4 weeks of treatment. Further study with higher capsaicin concentration<br>and/or larger size patch should be considered.</p> ER -