TY - JOUR AU - Siriwasunthra, Siripailin AU - Korphaisarn, Krittiya AU - Sirivatanauksorn, Yongyut AU - Limsrichamrern, Somchai AU - Mahawithitwong, Prawej AU - Kositamongkol, Prawat AU - Tovikkai, Chutwichai AU - Asavakarn, Supreecha AU - Chanduayvit, Fern AU - Pongpaibul, Ananya PY - 2018/10/30 Y2 - 2024/03/29 TI - Obesity Significantly Affects the Incidence of Hepatic Injury in Patients with Colorectal Liver Metastasis JF - Siriraj Medical Journal JA - Siriraj Med J VL - 70 IS - 5 SE - Original Article DO - UR - https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/152670 SP - 429-437 AB - <p><strong>Objective</strong>: Surgical resection is the mainstay treatment for colorectal liver metastasis. In unresectable cases,<br>chemotherapy is used to transform the tumor into resectable lesions, with related concerns about toxicity to nontumoral<br>liver parenchyma. Liver toxicity, including steatosis, steatohepatitis, and sinusoidal dilation, has been<br>reported. However, these changes are difficult to histologically distinguish from non-alcoholic fatty liver disease,<br>which is commonly found in populations and attributed mainly to metabolic syndrome. The aim of this study was<br>to investigate the factors associated with liver injury in patients with colorectal liver metastasis.<br><strong>Methods</strong>: This retrospective study included the patients who underwent hepatic resection for colorectal liver metastasis<br>at Siriraj Hospital during the eight-year period (2006 to 2013). Patient demographic data, clinical characteristics,<br>and histologic changes related to liver injury were collected and analyzed. Ten factors were evaluated for association<br>with liver injury in selected patients.<br><strong>Results</strong>: Ninety-two patients (50 men, 42 women) were included, with a mean age of 59.4 years (range: 48.5-70.3).<br>Forty-four patients (47.8%) received preoperative chemotherapy (CMT). Incidence of liver injury was not significantly<br>different between the CMT and non-CMT groups (65.9% vs. 62.5%; p=0.902). However, incidence of liver injury<br>was significantly higher in obese patients than in non-obese patients (82.8% vs. 55.6%; p=0.022, odds ratio=3.95).<br>Multivariate analysis showed that obesity (BMI &gt;25 kg/m2) was the only factor significantly associated with liver<br>injury in patients with colorectal liver metastasis.<br><strong>Conclusion</strong>: Of the ten factors evaluated, obesity was the only factor found to be significantly associated with liver<br>injury in patients with colorectal liver metastasis.</p> ER -