TY - JOUR AU - Ngamsombat, Chanon AU - Dechasasawat, Thanapat AU - Wongsripuemtet, Jitsupa AU - Charnchaowanish, Panida AU - Muangpaisan, Weerasak AU - Chawalparit, Orasa PY - 2019/03/28 Y2 - 2024/03/29 TI - The Evaluation of Posterior Cingulate Gyrus by Diffusion Tensor Imaging in Alzheimer’s Disease Patients Compared with Normal Control Subjects JF - Siriraj Medical Journal JA - Siriraj Med J VL - 71 IS - 2 SE - Original Article DO - 10.33192/Smj.2019.18 UR - https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/180748 SP - 117-122 AB - <p><strong>Objective:</strong> Posterior cingulate gyrus atrophy is found in early clinical stage of Alzheimer’s disease (AD) patients.1<br>Diffusion tensor imaging (DTI) can be used for evaluating microstructure change in brain parenchyma.2 Our<br>objective was to compare the microstructural change at posterior cingulate gyrus between AD patients and normal<br>control subjects by using DTI.<br><strong>Methods:</strong> The retrospective review of 23 AD patients, diagnosed by NINCDS-ADRDA with available MRI data<br>including DTI, and 19 normal control subjects was performed. The DTI parameters of posterior cingulate gyrus of<br>each group were analyzed and compared.<br><strong>Results:</strong> The mean diffusivity (MD), axial diffusivity and radial diffusivity (RD) of posterior cingulate gyrus were<br>significantly increased in AD patients compared with normal control subjects (p value &lt;0.001, &lt;0.001, &lt;0.001,<br>respectively). The fractional anisotropy (FA) was slightly decreased in AD patients compared with normal control<br>subjects but did not reach statistical significance (p value=0.71).<br><strong>Conclusion:</strong> Microstructural change at posterior cingulate gyrus demonstrated by DTI parameters including MD,<br>axial diffusivity and RD were significantly different between AD patients and normal control subjects. These results<br>were probably helpful for early diagnosis, evaluation, and follow up of the AD patients as correlate with clinical<br>findings.</p> ER -