TY - JOUR AU - Wongtiraporn, Weerasak AU - Luenee, Pusadee AU - Opartkiattikul, Nisarat AU - Wongtiraporn, Wanida AU - Wongtiraporn, Wanida AU - Laiwejpithaya, Somsak AU - Sangkarat, Suthi AU - Laiwejpithaya, Sujera PY - 2020/03/31 Y2 - 2024/03/29 TI - Tissue Factor Expression of Endothelial Cell in Response to Atherosclerotic Risk Factors JF - Siriraj Medical Journal JA - Siriraj Med J VL - 63 IS - 1 SE - Original Article DO - UR - https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/240817 SP - 1-3 AB - <p><strong>Objective:</strong> To study the effect of serum from patients with atherosclerotic risk factors on the synthesis of endothelial tissue factor.<br><strong>Methods:</strong> Serum from 30 diabetic patients, 30 hyperlipemic patients, 30 smokers and 30 normal serum were incubated with cultured endothelial cells from a human umbilical vein. The tissue factor of endothelial cells was measured using the assay that was developed in house after 24 hours incubation time.<br><strong>Results:</strong> Smokersั serum can significantly cause the increase in endothelial tissue factor. The mean level of tissue factor induced by smokersั serum is 1.12 microunits/cell whereas the mean level of tissue factor induced by diabetic serum, hyperlipemic serum and normal serum is 0.4, 0.48 and 0.2 microunit/cell, respectively.<br><strong>Conclusion:</strong> Smoking may increase the risk of thrombosis by increasing the tissue factor production of endothelial cells.</p> ER -