TY - JOUR AU - Wongkornrat, Wanchai AU - Sriyoscharti, Somchai AU - Laksanabunsong, Pansak AU - Phanchaipetch, Teeravit AU - Subtaweesin, Thaworn AU - Thongchareon, Punnarerk AU - Sakiyalak, Pranya AU - Slisatkorn, Worawong AU - Opartkiattikul, Nisarat PY - 2020/04/03 Y2 - 2024/03/29 TI - Comparison of Intensity of Platelet Aggregation between Patients Receiving Low and High Aspirin Dosage in Post CABG Patients JF - Siriraj Medical Journal JA - Siriraj Med J VL - 63 IS - 6 SE - Original Article DO - UR - https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/241005 SP - 187-190 AB - <p><strong>Background:</strong> Aspirin used after coronary artery bypass graft surgery (CABG) improved patient survival and reduced graft<br>thrombosis. However, individual variations in the antiplatelet effect of aspirin have been reported among CABG patients.<br><strong>Objective:</strong> To compare the intensity of platelet aggregation between patients receiving low and high aspirin dosage in post<br>CABG patients.<br><strong>Methods:</strong> We prospectively studied the effect of aspirin dosage on platelet aggregation in 100 CABG patients. Oral aspirin<br>was discontinued prior to CABG and re-started within 12 hours after CABG. Blood samples were collected and transferred<br>to a laboratory prior to surgery then again on postoperative days two and eight for platelet aggregation test and platelet count<br>within three hours after venipuncture.<br><strong>Results:</strong> One hundred patients (sixty five male and thirty five female patients) post coronary artery bypass graft (CABG) were<br>evaluated for eligibility to enter the trial. The percentage of platelet aggregation was compared between low dose (&lt;100 mg/<br>day), and high dose (&gt;100 mg/day) aspirin, at postoperative CABG days 2 and 8, which showed no significant difference for<br>the platelet aggregation (p = 0.161 post CABG day 2 and p = 0.098 post CABG day 8).<br><strong>Conclusion:</strong> Low dosage aspirin should be used in post CABG patients because the intensity of platelet aggregation between<br>patients post CABG receiving low and high aspirin dosage were not different, while the prophylactic effect of the low aspirin<br>dosage in reducing the risk of cardiovascular events proved equally as effective as the high aspirin dosage.</p> ER -