TY - JOUR AU - Sotthibundhu, Areechun AU - Buntup, Doungjai AU - Sanghirun, Channarong AU - Cherdchu, Korbkit AU - Cheeramakara, Cheeraratana AU - Chansirikarnjan, Sirintorn AU - Nimkulrat, Ekapot AU - Udommongkol, Chesda AU - Wongmek, Wanna AU - Thangnipon, Wipawan PY - 2008/01/01 Y2 - 2024/03/29 TI - Low Serum Vitamin B12 in Alzheimerûs Patients as Detected by a Solid Phase Radioimmunoassay JF - Siriraj Medical Journal JA - Siriraj Med J VL - 60 IS - 1 SE - Original Article DO - UR - https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/246322 SP - 66-68 AB - <p>Objective: To determine the relationship between serum levels of vitamin B12 and folate in AD and other types of dementia in Thai patients.<br>Methods: One hundred and eleven Thai subjects were classified into 3 groups: 32 AD patients, 43 non-AD dementia patients and 36 age-matched controls. Serum concentrations of vitamin B12 and folate were measured using a solid phase radioimmunoassay.<br>Results: Serum vitamin B12 levels were found to be significantly lower in AD and non-AD dementia patients than in age-matched controls. There is a significant relationship between Mini-Mental State Examination score and vitamin B12 level in AD and non-AD dementia groups. However, there is no significant difference in serum folate in AD and non-AD dementia groups when compared to age-matched controls.<br>Conclusion: These findings suggest the need for vitamin B12 supplementation in AD and non-AD dementia patients.</p> ER -