https://he02.tci-thaijo.org/index.php/sirirajmedj/issue/feed Siriraj Medical Journal 2025-02-02T20:42:24+07:00 Professor Thawatchai Akaraviputh thawatchai.aka@mahidol.ac.th Open Journal Systems <p>The Siriraj Medical Journal (SMJ) is an open access, double-blind peer-reviewed, monthly international journal that considers articles on biomedical sciences on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions.</p> <p>Studies must be scientifically valid; for research articles this includes a scientifically sound research question, the use of suitable methods and analysis, and following community-agreed standards relevant to the research field.</p> <p><strong>Online ISSN</strong> 2228-8082</p> https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/272188 Association between Grit and Burnout among Clinical Medical Students 2025-02-02T20:41:57+07:00 Nirucha Thamwiriyakul nunamchah@gmail.com Supitcha Thamissarakul supitchatham@gmail.com Prakasit Wannapaschaiyong prakasit.wan@mahidol.ac.th <p><strong>Objective:</strong> The purpose of this study was to determine the relationship between grit and burnout among clinical medical students.</p> <p><strong>Material and Methods:</strong> A cross-sectional descriptive study was conducted between December 2023 and January 2024 at the Chonburi Medical Education Center. Data from 106 clinical medical students were gathered using the 8-item Short Grit scale and the Maslach Burnout Inventory General Survey. Descriptive statistics, Pearson’s correlation, and logistic regression were used to analyze the data.</p> <p><strong>Results:</strong> Among the 106 clinical medical students, 52.8% met the criteria for burnout syndrome. 44.3% had high levels of emotional exhaustion and 32.1% had high levels of depersonalization. However, most of these medical students had moderate levels of total grit, passion, and perseverance. Pearson’s correlation analysis showed that total grit and perseverance scores were negatively correlated with emotional exhaustion and positively correlated with personal accomplishments. Further analysis using multivariate logistic regression revealed that burnout syndrome in clinical medical students was significantly associated with high-demand ward responsibility (AOR 3.189, p = 0.012) and low levels of total grit (AOR 7.147, p = 0.023).</p> <p><strong>Conclusion:</strong> Burnout is prevalent among clinical medical students, particularly among those with high-demand ward responsibilities and low grit levels. Higher grit, especially perseverance, is associated with reduced emotional exhaustion and greater personal accomplishments. Enhancing grit may help mitigate burnout among this population.</p> 2025-02-01T00:00:00+07:00 Copyright (c) 2024 Siriraj Medical Journal https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/271976 The Effect of the Thai Herbal Suksaiyad Formula on Platelet Aggregation in Healthy Volunteers: A Quasi-experimental, Single-dose Study 2025-02-02T20:42:11+07:00 Titchaphorn Palo titchaporn.pal@mahidol.edu Nalinthika Nathananwanit nalinthika.nat@mahidol.edu Pravit Akarasereenont pravit.auk@mahidol.ac.th Suksalin Booranasubkajorn suksalin.boo@mahidol.edu <p><strong>Objective:</strong> To investigate the effects of the Thai Herbal Suksaiyad formula (SSF) on platelet aggregation in healthy volunteers.</p> <p><strong>Material and Methods:</strong> In a quasi-experimental study, thirty healthy volunteers received a single dose of 2,000 mg SSF. Blood samples were taken at 0, 3, 6, and 24 hours after SSF administration for platelet aggregation analysis using aggregometry. Platelets were induced with epinephrine, adenosine diphosphate, and collagen.</p> <p><strong>Results:</strong> SSF significantly decreased platelet aggregation at 3 and 6 hours post-administration. Sub-analysis revealed no significant differences between males and females. SSF significantly decreased platelet aggregation in normal and hyperaggregation groups but had no effect on the disaggregation group. The effect of SSF was short-lived, reverting to pre-dose values after 24 hours for all agonists. Adverse events included flatulence (1 participant) and diarrhea (1 participant).</p> <p><strong>Conclusion:</strong> Caution is advised when using SSF in patients with blood disorders. Potential herb-drug interactions between SSF and drugs that impact platelet aggregation, such as aspirin, should be closely monitored. These interactions could result in fluctuations that may enhance or diminish the effectiveness of concurrent antiplatelet therapies, potentially increasing the risk of bleeding or decreasing therapeutic outcomes.</p> 2025-02-01T00:00:00+07:00 Copyright (c) 2024 Siriraj Medical Journal https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/271916 Correlation between Obesity and Left Atrial Enlargement in Patients Using Cardiac Magnetic Resonance 2025-02-02T20:42:24+07:00 Solos Jaturapisanukul solos@nmu.ac.th Yodying Kaolawanich yodying.kao@gmail.com Methat Meechuen methat.mee@outlook.co.th Thananya Boonyasirinant drthananyaa@yahoo.com <p><strong>Objective:</strong> The correlation between left atrial (LA) enlargement and obesity has been previously reported. However, most studies primarily evaluated LA diameter using echocardiography, which is less accurate and reliable than assessing LA volume with cardiac magnetic resonance (CMR). This study aimed to explore the correlation between obesity and LA volume by using CMR imaging.</p> <p><strong>Materials and Methods:</strong> We prospectively enrolled consecutive eligible patients aged 18 years or older who underwent CMR at a tertiary academic hospital. Clinical variables, including body mass index (BMI), were collected from the medical records. LA volume classification was based on the current guideline recommendations.</p> <p><strong>Results:</strong> A total of 140 patients (41% men), with a mean age of 66.5 ± 10.5 years, were studied. The mean BMI was 25.7 ± 4.2 kg/m2. CMR parameters revealed an LA volume of 75.7 ± 22.5 mL, a left ventricular (LV) ejection fraction of 71.1 ± 9.5%, and an LV mass index of 46.1 ± 27.4 g/m2. Univariable analysis indicated that the factors affecting LA volume included BMI (r = 0.3, p &lt; 0.001), LV mass index (r = 0.3, p = 0.001), waist circumference (r = 0.3, p &lt; 0.001), male sex (p = 0.01), and hypertension (p = 0.01). In stepwise multivariable analysis, BMI (p &lt; 0.001), LV mass index (p = 0.02), and male sex (p = 0.03) were independently associated with LA volume.</p> <p><strong>Conclusion:</strong> Obesity, as represented by BMI, was independently associated with LA enlargement. Other independent factors correlated with LA volume included the LV mass index and male sex.</p> 2025-02-01T00:00:00+07:00 Copyright (c) 2024 Siriraj Medical Journal https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/271719 Validation of Self-application-based Malnutrition and Limited Mobility Screening Tools Compared with Standard Diagnostic Tools in Older Adults 2025-01-02T13:57:57+07:00 Panvadee Tanaviboon annabenaann@gmail.com Weerasak Muangpaisan drweerasak@gmail.com Angkana Jongsawadipatana ajongsawad@gmail.com Pitiporn Siritipakorn pitiporn.sir@gmail.com Somboon Intalapaporn sintalapaporn@gmail.com <p><strong>Objective:</strong> To validate application screening tools against face-to-face standard tools (the Mini Nutritional Assessment (MNA) and Short Physical Performance Battery test (SPPB)) in older adults.</p> <p><strong>Materials and Methods:</strong> A mobile or tablet application was developed based on user interfaces and experiences. Outpatients aged 60 years and over were tested with this tool. We used 2 questions from the WHO-ICOPE algorithm and 3 questions from the STEADI algorithm to screen for at-risk malnutrition and limited mobility, respectively. The MNA and SPPB were used to detect malnutrition and limited mobility, respectively, to test their validity.</p> <p><strong>Results:</strong> The study involved 187 participants, 16% of whom were diagnosed with at-risk malnutrition by the MNA and 18.7% of whom had limited mobility according to the SPPB. The sensitivity and specificity of the malnutrition application tool were 66.6% and 96.1%, respectively. When BMI &lt; 18.5 was combined in the application, the sensitivity and specificity were 90% and 91%, respectively. For limited mobility, the sensitivity and specificity of the application were 94.2% and 76.3%, respectively. The majority of participants rated the application for easy understanding as «excellent» (65%) and rated their confidence in their ability to use the application by themselves as “excellent” (70%).</p> <p><strong>Conclusion:</strong> The application is an age-friendly, time-saving tool that can be used when face-to-face screening is vdifficult with good validity.</p> 2025-01-01T00:00:00+07:00 Copyright (c) 2024 Siriraj Medical Journal https://he02.tci-thaijo.org/index.php/sirirajmedj/article/view/271734 Prevalence of Geriatric Syndromes and Satisfaction of Service in Older People Receiving Annual Health Screening at the Check-up Clinic, Siriraj Hospital 2025-01-02T13:57:53+07:00 Harisd Phannarus hphannarus@gmail.com Supakorn Chansaengpetch chans.supakorn@gmail.com Tirathat Virojskulchai tirathat_v@hotmail.com Napaporn Pengsorn npp.2145@hotmail.com Pensri Chaopanitwet pensri.cha@mahidol.ac.th Usa Vannachavee uwn755@gmail.com Jirawit Wong-ekkabut jirawit.w@hotmail.com Ananya Treewisoot ananya2535blue@gmail.comt Sunun Thanasamut sunun.hlan@gmail.com Angkana Jongsawadipatana ajongsawad@gmail.com Weerasak Muangpaisan drweerasak@gmail.com <p><strong>Objective:</strong> To assess the prevalence of geriatric syndromes (GSs) and evaluate service satisfaction among older patients attending a comprehensive geriatric check-up clinic (CGCC) at Siriraj Hospital.</p> <p><strong>Materials and Methods:</strong> A cross-sectional study was conducted at the CGCC from December 2021 to November 2022. Participants aged 60 years and older were screened using a two-step approach; short screening by a standard questionnaire followed by an in-depth assessment. GSs were identified through standardized tools, and patient satisfaction was assessed using a structured questionnaire.</p> <p><strong>Results:</strong> Of 159 participants, 67.9% were women, with a mean age of 66.6 ± 6 years. In step 1, 43.7% showed cognitive impairment, 29.1% had a risk of falls, and 76% reported oral health issues. Step 2 confirmed cognitive impairment in 40.6%, malnutrition risk in 93.3%, and sarcopenia in 78%. The mean satisfaction score was 33.3 ± 2.5 out of 35 points. Total service time averaged 104.2 ± 36.9 minutes.</p> <p><strong>Conclusion:</strong> In a health check-up clinic where GSs are often under-recognized, GSs, particularly cognitive impairment, fall risk, and oral health issues, are prevalent. Despite extended service times, patient satisfaction remained high, highlighting the importance of comprehensive screening in geriatric care.</p> 2025-01-01T00:00:00+07:00 Copyright (c) 2024 Siriraj Medical Journal