Effects of vitamin E and curcuminoids supplement in thalassemia

Abstract

Thalassemias are a family of genetic disorder. All are characterized by quantitative defect of globin synthesis. Thedeleterious consequences of the globin that produces in excess are responsible for the ineffective erythropoiesisand shortened red cell survival. Thalassemia is characterized by anemia, iron overload as well as oxidative stress,an imbalance between antioxidant and oxidant status. Although oxidative stress is not the primary etiology of thethalassemia, it mediated several of their pathological processes, including haemolysis. The supplementation of vitamin Eand curcuminoid in thalassemia did not have any toxic and side effect. Moreover, the antioxidant capacity of bothcompounds resulted in a significant increase in antioxidant status concomitant with decrease oxidant free radical inthalassemia. However, these antioxidants have not yet been shown to improve the anemia of thalassemia patient.Therefore, synergistic effect of these compounds with others therapy such as blood transfusion and iron chelator maybe a promising strategy for alleviating pathology associated to oxidative stress in thalassemia patient.

Key words: Thalassemia, Vitamin E, Curcuminoids, Antioxidant