Pregnancy outcomes in human immunodefi ciency virus (HIV)-infected pregnant women who received active antiretroviral therapy at Saraburi Hospital

Abstract

Objective: To estimate the risks of adverse pregnancy outcomes in HIV-infected pregnant women, who receivedantiretroviral therapy, compared with the non-infected pregnant women.

Method: A retrospective cohort study recruited 512 women who delivered at Saraburi hospital between 1^st January1999 and 31^st December 2011. We compared 206 HIV–infected pregnant women who receivedantiretroviral drug with 206 non-infected pregnant women in terms of pregnancy outcomes. Both groupswere delivered after 20 weeks gestation, and matched each group by age, gravidity and number of parity.

Results: Compared with the non-infected women, HIV-infected pregnant women who received antiretroviral drughad a statistically signifi cant increase in adverse pregnancy outcomes including preeclampsia (adjustedOR = 2.85, 95%CI 1.05-7.72), preterm birth (adjusted OR = 1.78, 95%CI 1.01-3.15), maternal anemia(adjusted OR = 3.57, 95%CI 2.32-5.48), postpartum hemorrhage (adjusted OR = 3.97, 95%CI 1.23-12.82)and low infant birth weight (adjusted OR = 3.33, 95%CI 1.38-8.04).

Conclusion: HIV-infected pregnant women who received antiretroviral therapy were at higher risk for adversepregnancy outcomes. For decrease of serious complication, clinicians should be aware for risks. High riskobstetrical care is required.

Key words: Antiretroviral drug, Human immunodefi ciency virus, Preterm birth, Maternal anemia, Postpartum hemorrhage