Risk factor associated with cholangiocarcinoma, Satuek hospital, Buriram province, Thailand

Abstract

Introduction: Cholangiocarcinoma (CHCA) is a major public health problem in Thailand especially in the Northeasternregion. Risk factors related to CHCA patient is necessary for government to plan for future preventionand management. Therefore, this study aimed to identify the significant risk factors found in patients withCHCA who were serviced in Satuek hospital, Buriram province, during the years 2008 and 2012.

Method: Retrospective analytical study was performed. 53 patients with CHCA and 174 healthy controls wererecruited included in this study for evaluate risk factors of CHCA.

Result: 53 patients with CHCA were studied. The male and female ratio was 2.12:1. The average age was67 years old (62 - 73 years old). Univariate analysis revealed that risk factors that were statisticallysignificant in relation to CHCA were: age over 40 years old (OR = 46.34, 95%CI = 6.26 - 342.81),cholethiasis (OR = 36.00, 95%CI = 4.44 - 291.89), body mass index with less than 25 kg./m² (OR = 3.78,95%CI = 1.10 - 12.89), alcohol consumption (OR = 1.91, 95%CI = 1.008 - 3.62) and male (OR = 2.79,95%CI = 1.45 - 5.35). Multivariate analysis narrowed down statistically factors to: age over 40 years old(AOR = 34.77, 95%CI = 4.64 - 260.50), cholethiasis (AOR = 22.05, 95%CI = 2.61 - 185.87) and male(AOR = 2.33, 95%CI = 1.03 - 5.28).

Discussion and Conclusion: Risk factors related to the patients with CHCA were male, age over 40 years old, body mass index with less than 25 kg./m², cholethiasis and alcohol consumption. This study indicates that CHCA is still a publichealth problem in Buriram province and identifies some related factors to help in health education andrisk factors campaign in the future.

Key words: Risk factors, Cholangiocarcinoma, Buriram