Pharmacological treatment for Alzheimer’s disease

Abstract

Pharmacological treatment for Alzheimer’s disease has been progressing for the past decade. The approvedmedications are acetylcholinesterase inhibitors (AChEI) and memantine. Current treatment guidelines recommend AChEI formild to moderate disease and memantine for moderate to severe disease or intolerability to AChEI. Treating physician shouldperiodically monitor their side effect as well as efficacies. Other drugs such as antioxidants and anti-inflammatory agentswere not proven to be effective. Immunotherapy is the novel treatment strategy which may directly affect Alzheimer’spathology. It either inhibits the accumulation or eliminates Abeta or amyloid protein in the brain.

Key words: Pharmacological treatment, Alzheimer’s disease, Acetylcholinesterase inhibitors, Memantine, Antioxidants,Anti-inflammatory agents, Immunotherapy