Effect of Bupivacaine on Preperitoneal in Laparoscopic Total Extraperitoneal Hernioplasty: Prospective Randomized Double Blind Controlled Trial
Keywords:
bupivacaine, preperitoneal, laparoscopic total extraperitonealhernioplasty inguinal herniaAbstract
Objectives: The aim of the study was to evaluate the analgesic effect after instillation of bupivacaine in preperitoneal space in patients undergoing unilateral laparoscopic totally extraperitoneal (TEP) hernioplasty.
Methods: A total of 44 patients with unilateral reducible inguinal hernia were randomly assigned into two groups. The bupivacaine group received 40 mL of 0.25% bupivacaine, and the control group received 40 mL of normal saline, instilled into the preperitoneal space during the TEP procedure. Surgeons, anesthesiologists, and patients were blinded to the assigned treatments. A nurse assessor also blindly assessed the pain score, using the visual analogue scale (VAS) and the numeric rating scale (NRS). Postoperative pain scores were recorded at 2, 4, 8, 12, 24 hours after operation. Complications, time of first analgesia and fentanyl consumption were recorded. All operations were performed by one surgeon.
Results: The age, sex, BMI, operative time did not significantly differ between the two groups. Similarly, there were no significant differences between groups with regard to postoperative pain, time to first analgesia, fentanyl consumption and complications.
Conclusions: The instillation of bupivacaine in the preperitoneal space during laparoscopic totally extraperitoneal hernioplasty did not reduce postoperative pain compared with placebo. The study was registered on www.clinicaltrial.in.th with number TCTR2016712004
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