Prevalence and Risk Factor of Chronic Kidney Disease after Unilateral Nephrectomy in Patients with Renal Calculi
Keywords:
CKD, glomerular filtration rate, unilateral nephrectomy, renal calculiAbstract
Objective: To study risk factor affecting changes in glomerular filtration rate (GFR) and a prevalence ofchronic kidney disease (CKD) after unilateral nephrectomy in patients with renal calculi.
Methods: We retrospectively studied 65 patients who underwent unilateral nephrectomy at least 12 months
before study between March 2006 and September 2014. The GFR of the individual patients was estimated by using
CKD-EPI formula before and after nephrectomy. By performing univariate and multivariate regression analysis, we
evaluated the risk factors that affect changes in GFR, such as age, sex, body mass index (BMI), preoperative GFR,
presence of diabetes mellitus (DM), presence of hypertension (HTN), presence of dyslipidemia (DLP) and duration
of follow up after nephrectomy.
Results: Prevalence of CKD was 22.64%. We found that male was the only risk factor that statistically
significantly associated with CKD by univariate and multivariate regression analysis (Odds ratio 7.619 [1.516-38.303],
p = 0.006; Odds ratio 7.347 [1.419-38.049, p = 0.017, respectively). The change of GFR was not significantly
influenced by age, BMI, preoperative GFR, DM, HTN, DLP and duration of follow up after nephrectomy.
Conclusions: A prevalence of CKD was 22.64% and significant risk factor for CKD in our study was male gender.
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carcinoma before and after radical or partial nephrectomy.
Jpn J Clin Oncol 2013;43(12):1243-8.
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disease. Gend Med 2008;5 Suppl:S3-S10.
16. Gandolfo MT , Verzola D, Salvatore F, et al. Gender and the
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the difference ? Mine Urol Nefrol 2004; 56 (1):1-14.
17. Grzegorczyk K, Krajewska M, Weyed W, et al. Gender and
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2. Wafa EW, Refaie AF, Abbas TM, et al. End-stage renal
disease among living-kidney donors: single-center
experience. Exp Clin Tran 2011; 9(1):14-9
3. Tsai SF, Shu KH, Ho HC, et al. Long - term outcomes of living
kidney donors over the past 28 years in a single center in
Taiwan. Tran Proc 2012; 44(1):39-42.
4. William CH, Andrew SL, Angel MS, et al. Chronic kidney
disease after nephrectomy in patients with renal cortical
tumours: a retrospective cohort study. Lanc Oncol 2008,
7(9):735-40.
5. Fiona Mei Wen W, Melissa Hui Wen T, Zhaojin C, et al.
Postoperative risk of chronic kidney disease in radical
nephrectomy and donor nephrectomy patients: a
comparison and analysis of predictive factors. Can J Urol
2014;21(4):7351-7.
6. Cho A, Lee JE, Know GY, et al. Post - operative acute kidney
injury in patients with renal cell carcinoma is a potent risk
factor for new - onset chronic kidney disease after radical
nephrectomy. Neph Dial Tran 2011;26(11):3496-501.
7. Gansevoort RT, Correa-Rotter R, Hemmel Garn BR, et al.
Chronic kidney disease and cardiovascular risk: epidemiology,
mechanisms, and prevention. Lancet 2013;382
(9889):339-52.
8. Ito S. Cardio renal connection in chronic kidney disease.
Clin Exp Neph 2012;16(1):8-16.
9. Chareiere S, regnant N, Chiche F, et al. [Chronic renal
insufficiency and cardiovascular disease] . And Card Ange
(paris) 2009 ;58(1):40-52.
10. Kutyrina IM, Rudenko TE, Saveeva SA , ET al. Risk factors for
cardiovascular system damage in chronic kidney disease.
Ter Arkh 2013;85(9):69-76.
11. Manuel P, Eduardo H, Juan Carlos H, et al. Influence of
obesity on the appearance of proteinuria and renal
insufficiency after unilateral nephrectomy. Kidney Int 2000;
58:2111-8.
12. Tan L, Tai BS, Wu F, et al. Impact of kidney disease outcomes
quality initative guidelines on the prevalence of chronic
kidney disease after living donor nephrectomy. J Urol 2011;
185(5):1820-5.
13. Kim SH, Lee SE, Hong SK, et al. Incidence and risk factors of
chronic kidney disease in Korean patients with T1 a renal cell
carcinoma before and after radical or partial nephrectomy.
Jpn J Clin Oncol 2013;43(12):1243-8.
14. Mark JS, Andriw SL, Anton C, et al. Kidney disease as a risk
factor for development of cardiovascular disease. Circ
2003;108:2154-69.
15. Silbiger S, Neugarten J. Gender and human chronic renal
disease. Gend Med 2008;5 Suppl:S3-S10.
16. Gandolfo MT , Verzola D, Salvatore F, et al. Gender and the
progression of chronic renal disease: does apoptosis make
the difference ? Mine Urol Nefrol 2004; 56 (1):1-14.
17. Grzegorczyk K, Krajewska M, Weyed W, et al. Gender and
kidney disease: the clinical importance and mechanisms of
modifying effects. Post Hig Med Dosw 200;65:849-57.
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Published
2016-10-01
How to Cite
1.
Seubsang B. Prevalence and Risk Factor of Chronic Kidney Disease after Unilateral Nephrectomy in Patients with Renal Calculi. Thai J Surg [Internet]. 2016 Oct. 1 [cited 2024 May 6];37(4). Available from: https://he02.tci-thaijo.org/index.php/ThaiJSurg/article/view/225984
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