Management and Outcome of Ruptured Hepatocellular Carcinoma

Authors

  • Surawut Charoenkajonchai General Surgery Unit, Department of Surgery, Chonburi Hospital, Chonburi 20000, Thailand

Keywords:

Ruptured, hepatocellular carcinoma, management, outcome

Abstract

This study reviewed 84 patients with ruptured hepatocellular carcinoma (HCC) who were treated at Chonburi
Hospital during 2006-2012. There were 72 males and 12 females. In acute management, 52 were treated conservatively,
23 were treated by transarterial embolization (TAE), 5 were treated by surgery followed by TAE and 4 were treated by
surgery alone. Overall 30-day mortality was 61.9%. Factors related to early mortality are Child’s classification, MELD
score and age. Four patients underwent delayed hepatectomy as a definitive treatment. The median survival after
hepatectomy was more than 34 months. The longest follow up was a patient who underwent delayed hepatectomy as
a definitive treatment and remained disease-free after 60 months. Hepatectomy should be considered as a definitive
treatment for ruptured HCC in delayed phase. A suitable candidate for hepatectomy is a patient who has good
performance status and normal liver function.

References

1. Liu CL, Fan ST, Lo CM, et al. Management of spontaneous
rupture of hepatocellular carcinoma: single-center
experience. J Clin Oncol 2001;19:3725-32.

2. Chen CY, Lin XZ, Shin JS, et al. Spontaneous rupture of
hepatocellular carcinoma. A review of 141 Taiwanese cases
and comparison with nonrupture cases. J Clin Gastroenterol
1995;21:238-42.

3. Kim Y-I, Ki H-S, Kim M-H, et al. [Analysis of the clinical
characteristics and prognostic factors of ruptured hepatocellular carcinoma]. Korean J Hepatol 2009;15:148-
58. [Abstract]

4. Pawarode A, Voravud N. Ruptured primary hepatocellular
carcinoma at Chulalongkorn University Hospital: a
retrospective study of 32 cases. J Med Assoc Thai 1997;80:
706-14.

5. Castells L, Moreiras M, Quiroga S, et al. Hemoperitoneum as
a first manifestation of hepatocellular carcinoma in western
patients with liver cirrhosis: effectiveness of emergency
treatment with transcatheter arterial embolization. Dig Dis
Sci 2001;46:555-62.

6. Chearanai O, Plengvanit U, Asavanich C, Damrongsak D,
Sindhvananda K, Boonyapisit S. Spontaneous rupture of
primary hepatoma: report of 63 cases with particular
reference to the pathogenesis and rationale treatment by
hepatic artery ligation. Cancer 1983;51:1532-6.

7. Bassi N, Caratozzolo E, Bonariol L, et al. Management of
ruptured hepatocellular carcinoma: implications for therapy.
World J Gastroenterol 2010;16:1221-5.

8. Lai ECH, Lau WY. Spontaneous rupture of hepatocellular
carcinoma: a systematic review. Arch Surg 2006;141:191-8.

9. Tan FL-S, Tan Y-M, Chung AY-F, Cheow PC, Chow PK-H, Ooi
LL. Factors affecting early mortality in spontaneous rupture
of hepatocellular carcinoma. ANZ J Surg 2006;76:448-52.

10. Miyamoto M, Sudo T, Kuyama T. Spontaneous rupture of
hepatocellular carcinoma: a review of 172 Japanese cases.
Am J Gastroenterol 1991;86:67-71.

11. Lai EC, Wu KM, Choi TK, Fan ST, Wong J. Spontaneous
ruptured hepatocellular carcinoma. An appraisal of surgical
treatment. Ann Surg 1989;210:24-8.

12. Yang H, Chen K, Wei Y, et al. Treatment of spontaneous
ruptured hepatocellular carcinoma: A single-center study.
Pak J Med Sci 2014;30:472-6.

13. Leung CS, Tang CN, Fung KH, Li MKW. A retrospective review
of transcatheter hepatic arterial embolisation for ruptured
hepatocellular carcinoma. J R Coll Surg Edinb 2002;47:685-8.

14. Nouchi T, Nishimura M, Maeda M, Funatsu T, Hasumura Y,
Takeuchi J. Transcatheter arterial embolization of ruptured
hepatocellular carcinoma associated with liver cirrhosis.
Dig Dis Sci 1984;29:1137-41.

15. Chiappa A, Zbar A, Audisio RA, Paties C, Bertani E, Staudacher
C. Emergency liver resection for ruptured hepatocellular
carcinoma complicating cirrhosis. Hepatogastroenterology.
1999;46:1145-50.

16. Charoenkajonchai S. Synchronous resection of large
peritoneal implantation with right hemihepatectomy after
ruptured hepatocellular carcinoma: a case report. Chonburi
Hospital Journal 2011;36:93-8.

17. Yeh C-N, Lee W-C, Jeng L-B, Chen M-F, Yu M-C. Spontaneous
tumour rupture and prognosis in patients with hepatocellular
carcinoma. Br J Surg 2002;89:1125-9.

18. Shuto T, Hirohashi K, Kubo S, et al. Delayed hepatic resection
for ruptured hepatocellular carcinoma. Surgery 1998;124:33-7.

19. Vergara V, Muratore A, Bouzari H, et al. Spontaneous rupture
of hepatocelluar carcinoma: surgical resection and longterm
survival. Eur J Surg Oncol 2000;26:770-2.

Downloads

Published

2015-06-30

How to Cite

1.
Charoenkajonchai S. Management and Outcome of Ruptured Hepatocellular Carcinoma. Thai J Surg [Internet]. 2015 Jun. 30 [cited 2024 Dec. 23];36(2). Available from: https://he02.tci-thaijo.org/index.php/ThaiJSurg/article/view/226175

Issue

Section

Original Articles