The Role of Epidermal Growth Factor Receptor in Head and Neck Squamous Cell Carcinoma in Thai Patients
Keywords:
Head and neck cancer, EGFR, Squamous cell carcinomasAbstract
Introduction: Epidermal growth factor receptor (EGFR), a member of the type 1 tyrosine kinase familyof receptors, plays a crucial role in several types of cancer especially in squamous cell carcinoma of the head
and neck (HNSCC).
Objective: This study aimed to determine the frequency of EGFR overexpession in HNSCC and to find
the possible correlation with various clinical pathological parameters and patient outcomes.
Materials and Methods: Fresh cancerous tissues and matched normal mucosa were collected from 78
previously untreated HNSCC patients after obtaining informed consent. All patients had no detectable distant
metastases at presentation. EGFR mRNA expression were examined by quantitative real-time RT-PCR analysis.
Data were correlated with both clinicopathological characteristics and survival outcome.
Results: Overexpression of EGFR mRNA was found in 21 of 78 patients. EGFR expression was significantly
correlated with overall survival in univariate analysis.
Conclusions: EGFR expression plays an important role in the pathogenesis and progression of HNSCC.
References
1. Marcu LG, Yeoh E. A review of risk factors and genetic
alterations in head and neck carcinogenesis and
implications for current and future approaches to
treatment. J Cancer Res Clin Oncol 2009;135:1303-14.
2. Parkin DM BF, Ferlay J, Pisani P. Global cancer statistics, 2002.
A Cancer Jounal for Clinicians 2005;55:74-108.
3. Ang KK, Berkey BA, Tu X, Zhang HZ, Katz R, Hammond EH, et
al. Impact of epidermal growth factor receptor expression
on survival and pattern of relapse in patients with advanced
head and neck carcinoma. Cancer Res. 2002 D e c
15;62(24):7350-6.
4. Kim S, Grandis JR, Rinaldo A, Takes RP, Ferlito A. Emerging
perspectives in epidermal growth factor receptor targeting
in head and neck cancer. Head Neck 2008;30:667-74.
5. Rafferty MA, Fenton JE, Jones AS. An overview of the role
and inter-relationship of epidermal growth factor receptor,
cyclin D and retinoblastoma protein on the carcinogenesis
of squamous cell carcinoma of the larynx. Clin
Otolaryngol Allied Sci. 2001 Aug;26(4):317-20.
6. Takes RP, Baatenburg de Jong RJ, Wijffels K, Schuuring E,
Litvinov SV, Hermans J, et al. Expression of genetic markers
in lymph node metastases compared with their primary
tumours in head and neck cancer. J Pathol 2001;194:298-
302.
7. Ling L, Zhou MY, Wang HE. [Expression of EGFR and PCNA,
and DNA content in squamous cell carcinoma of larynx]. Lin
Chuang Er Bi Yan Hou Ke Za Zhi 2000;14:99-101.
8. Jin T, Yu CX, Lei DP, Liu DY, Xu FL, Lu YT, et al. Identification of
epidermal growth factor receptor (EGFR) exon 20 single
nucleotide polymorphism in Chinese squamous cell
carcinoma of head and neck (SCCHN). Acta Otolaryngol
2009;129:1306-12.
9. Werkmeister R, Brandt B, Joos U. Clinical relevance of erbB-
1 and -2 oncogenes in oral carcinomas. Oral Oncol
2000;36:100-5.
10. Schartinger VH JS, Wurm M, Schwentner IM, P. Obrist WO,
Sprinzl GM. The expression of EGFR, HER2 and EpCam in
Head and Neck squamous cell carcinomas. megazine of
european medical oncology. 2009:45-50.
11. Putti TC, To KF, Hsu HC, Chan AT, Lai GM, Tse G, et al.
Expression of epidermal growth factor receptor in head
and neck cancers correlates with clinical progression: a
multicentre immunohistochemical study in the Asia-Pacific
region. Histopathology 2002;41:144-51.
12. P Oc, Rhys-Evans PH, Archer DJ, Eccles SA. C-erbB receptors
in squamous cell carcinomas of the head and neck: clinical
significance and correlation withmatrix metalloproteinases
and vascular endothelial growth factors. Oral Oncol
2002;38:73-80.
13. Eriksen JG, Steiniche T, Askaa J, Alsner J, Overgaard J. The
prognostic value of epidermal growth factor receptor is
related to tumor differentiation and the overall treatment
time of radiotherapy in squamous cell carcinomas of the
head and neck. Int J Radiat Oncol Biol Phys 2004;58:561-6.
14. Sheikh Ali MA, Gunduz M, Nagatsuka H, Gunduz E, Cengiz B,
Fukushima K, et al. Expression and mutation analysis of
epidermal growth factor receptor in head and neck
squamous cell carcinoma. Cancer Sci. 2008;99:1589-94.
15. Huang SF, Chuang WY, Chen IH, Liao CT, Wang HM, Hsieh LL.
EGFR protein overexpression and mutation in areca quidassociated
oral cavity squamous cell carcinoma in Taiwan.
Head Neck. 2009;31:1068-77.
16. Temam S, Kawaguchi H, El-Naggar AK, Jelinek J, Tang H, Liu
DD, et al. Epidermal growth factor receptor copy number
alterations correlate with poor clinical outcome in patients
with head and neck squamous cancer. J Clin Oncol
2007;25:2164-70.
17. Farhadieh RD, Salardini A, Rees CG, Russell PJ, Yang JL,
Smee R. Protein expression of epidermal growth factor
receptor in laryngeal squamous cell carcinoma index tumors
correlates with diagnosis of second primary tumors of
the upper aero-digestive tract. Ann Surg Oncol 2009;16:2888-
94.
18. Shiga H, Rasmussen AA, Johnston PG, Langmacher M,
Baylor A, Lee M, et al. Prognostic value of c-erbB2 and other
markers in patients treated with chemotherapy for recurrent
head and neck cancer. Head Neck 2000;22:599-608.
19. Diniz-Freitas M, Garcia-Caballero T, Antunez-Lopez J,
Gandara-Rey JM, Garcia-Garcia A. Pharmacodiagnostic
evaluation of EGFR expression in oral squamous cell
carcinoma. Oral Dis 2007;13:285-90.
20. Khademi B, Shirazi FM, Vasei M, Doroudchi M, Gandomi B,
Modjtahedi H,et al. The expression of p53, c-erbB-1 and cerbB-
2 molecules and their correlation with prognostic
markers in patients with head and neck tumors. Cancer Lett
2002;184:223-30.
21. Hoffmann TK, Ballo H, Braunstein S, Van Lierop A, Wagenmann M, Bier H. Serum level and tissue expression of c-erbB-1 and
c-erbB-2 proto-oncogene products in patients with
squamous cell carcinoma of the head and neck. Oral
Oncol 2001;37:50-6.
22. Bei R, Pompa G, Vitolo D, Moriconi E, Ciocci L, Quaranta M,
et al. Co-localization of multiple ErbB receptors in stratified
epithelium of oral squamous cell carcinoma. J Pathol
2001;195:343-8.
23. Chen IH, Chang JT, Liao CT, Wang HM, Hsieh LL, Cheng AJ.
Prognostic significance of EGFR and Her-2 in oral cavity
cancer in betel quid prevalent area cancer prognosis. Br J
Cancer 2003;89:681-6.
24. Grandis JR, Zeng Q, Drenning SD, Tweardy DJ. Normalization
of EGFR mRNA levels following restoration of wild-type p53
in a head and neck squamous cell carcinoma cell line. Int
J Oncol 1998;13:375-8.
alterations in head and neck carcinogenesis and
implications for current and future approaches to
treatment. J Cancer Res Clin Oncol 2009;135:1303-14.
2. Parkin DM BF, Ferlay J, Pisani P. Global cancer statistics, 2002.
A Cancer Jounal for Clinicians 2005;55:74-108.
3. Ang KK, Berkey BA, Tu X, Zhang HZ, Katz R, Hammond EH, et
al. Impact of epidermal growth factor receptor expression
on survival and pattern of relapse in patients with advanced
head and neck carcinoma. Cancer Res. 2002 D e c
15;62(24):7350-6.
4. Kim S, Grandis JR, Rinaldo A, Takes RP, Ferlito A. Emerging
perspectives in epidermal growth factor receptor targeting
in head and neck cancer. Head Neck 2008;30:667-74.
5. Rafferty MA, Fenton JE, Jones AS. An overview of the role
and inter-relationship of epidermal growth factor receptor,
cyclin D and retinoblastoma protein on the carcinogenesis
of squamous cell carcinoma of the larynx. Clin
Otolaryngol Allied Sci. 2001 Aug;26(4):317-20.
6. Takes RP, Baatenburg de Jong RJ, Wijffels K, Schuuring E,
Litvinov SV, Hermans J, et al. Expression of genetic markers
in lymph node metastases compared with their primary
tumours in head and neck cancer. J Pathol 2001;194:298-
302.
7. Ling L, Zhou MY, Wang HE. [Expression of EGFR and PCNA,
and DNA content in squamous cell carcinoma of larynx]. Lin
Chuang Er Bi Yan Hou Ke Za Zhi 2000;14:99-101.
8. Jin T, Yu CX, Lei DP, Liu DY, Xu FL, Lu YT, et al. Identification of
epidermal growth factor receptor (EGFR) exon 20 single
nucleotide polymorphism in Chinese squamous cell
carcinoma of head and neck (SCCHN). Acta Otolaryngol
2009;129:1306-12.
9. Werkmeister R, Brandt B, Joos U. Clinical relevance of erbB-
1 and -2 oncogenes in oral carcinomas. Oral Oncol
2000;36:100-5.
10. Schartinger VH JS, Wurm M, Schwentner IM, P. Obrist WO,
Sprinzl GM. The expression of EGFR, HER2 and EpCam in
Head and Neck squamous cell carcinomas. megazine of
european medical oncology. 2009:45-50.
11. Putti TC, To KF, Hsu HC, Chan AT, Lai GM, Tse G, et al.
Expression of epidermal growth factor receptor in head
and neck cancers correlates with clinical progression: a
multicentre immunohistochemical study in the Asia-Pacific
region. Histopathology 2002;41:144-51.
12. P Oc, Rhys-Evans PH, Archer DJ, Eccles SA. C-erbB receptors
in squamous cell carcinomas of the head and neck: clinical
significance and correlation withmatrix metalloproteinases
and vascular endothelial growth factors. Oral Oncol
2002;38:73-80.
13. Eriksen JG, Steiniche T, Askaa J, Alsner J, Overgaard J. The
prognostic value of epidermal growth factor receptor is
related to tumor differentiation and the overall treatment
time of radiotherapy in squamous cell carcinomas of the
head and neck. Int J Radiat Oncol Biol Phys 2004;58:561-6.
14. Sheikh Ali MA, Gunduz M, Nagatsuka H, Gunduz E, Cengiz B,
Fukushima K, et al. Expression and mutation analysis of
epidermal growth factor receptor in head and neck
squamous cell carcinoma. Cancer Sci. 2008;99:1589-94.
15. Huang SF, Chuang WY, Chen IH, Liao CT, Wang HM, Hsieh LL.
EGFR protein overexpression and mutation in areca quidassociated
oral cavity squamous cell carcinoma in Taiwan.
Head Neck. 2009;31:1068-77.
16. Temam S, Kawaguchi H, El-Naggar AK, Jelinek J, Tang H, Liu
DD, et al. Epidermal growth factor receptor copy number
alterations correlate with poor clinical outcome in patients
with head and neck squamous cancer. J Clin Oncol
2007;25:2164-70.
17. Farhadieh RD, Salardini A, Rees CG, Russell PJ, Yang JL,
Smee R. Protein expression of epidermal growth factor
receptor in laryngeal squamous cell carcinoma index tumors
correlates with diagnosis of second primary tumors of
the upper aero-digestive tract. Ann Surg Oncol 2009;16:2888-
94.
18. Shiga H, Rasmussen AA, Johnston PG, Langmacher M,
Baylor A, Lee M, et al. Prognostic value of c-erbB2 and other
markers in patients treated with chemotherapy for recurrent
head and neck cancer. Head Neck 2000;22:599-608.
19. Diniz-Freitas M, Garcia-Caballero T, Antunez-Lopez J,
Gandara-Rey JM, Garcia-Garcia A. Pharmacodiagnostic
evaluation of EGFR expression in oral squamous cell
carcinoma. Oral Dis 2007;13:285-90.
20. Khademi B, Shirazi FM, Vasei M, Doroudchi M, Gandomi B,
Modjtahedi H,et al. The expression of p53, c-erbB-1 and cerbB-
2 molecules and their correlation with prognostic
markers in patients with head and neck tumors. Cancer Lett
2002;184:223-30.
21. Hoffmann TK, Ballo H, Braunstein S, Van Lierop A, Wagenmann M, Bier H. Serum level and tissue expression of c-erbB-1 and
c-erbB-2 proto-oncogene products in patients with
squamous cell carcinoma of the head and neck. Oral
Oncol 2001;37:50-6.
22. Bei R, Pompa G, Vitolo D, Moriconi E, Ciocci L, Quaranta M,
et al. Co-localization of multiple ErbB receptors in stratified
epithelium of oral squamous cell carcinoma. J Pathol
2001;195:343-8.
23. Chen IH, Chang JT, Liao CT, Wang HM, Hsieh LL, Cheng AJ.
Prognostic significance of EGFR and Her-2 in oral cavity
cancer in betel quid prevalent area cancer prognosis. Br J
Cancer 2003;89:681-6.
24. Grandis JR, Zeng Q, Drenning SD, Tweardy DJ. Normalization
of EGFR mRNA levels following restoration of wild-type p53
in a head and neck squamous cell carcinoma cell line. Int
J Oncol 1998;13:375-8.
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Published
2012-09-28
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1.
Sirikett H, O-Charoenrat P. The Role of Epidermal Growth Factor Receptor in Head and Neck Squamous Cell Carcinoma in Thai Patients. Thai J Surg [Internet]. 2012 Sep. 28 [cited 2024 Dec. 23];33(3). Available from: https://he02.tci-thaijo.org/index.php/ThaiJSurg/article/view/226886
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