The Role of Epidermal Growth Factor Receptor in Head and Neck Squamous Cell Carcinoma in Thai Patients

Authors

  • Hathainan Sirikett Department of Immunology, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
  • Pornchai O-Charoenrat Division of Head and Neck Surgery, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand

Keywords:

Head and neck cancer, EGFR, Squamous cell carcinomas

Abstract

Introduction: Epidermal growth factor receptor (EGFR), a member of the type 1 tyrosine kinase family
of receptors, plays a crucial role in several types of cancer especially in squamous cell carcinoma of the head
and neck (HNSCC).
Objective: This study aimed to determine the frequency of EGFR overexpession in HNSCC and to find
the possible correlation with various clinical pathological parameters and patient outcomes.
Materials and Methods: Fresh cancerous tissues and matched normal mucosa were collected from 78
previously untreated HNSCC patients after obtaining informed consent. All patients had no detectable distant
metastases at presentation. EGFR mRNA expression were examined by quantitative real-time RT-PCR analysis.
Data were correlated with both clinicopathological characteristics and survival outcome.
Results: Overexpression of EGFR mRNA was found in 21 of 78 patients. EGFR expression was significantly
correlated with overall survival in univariate analysis.
Conclusions: EGFR expression plays an important role in the pathogenesis and progression of HNSCC.

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Published

2012-09-28

How to Cite

1.
Sirikett H, O-Charoenrat P. The Role of Epidermal Growth Factor Receptor in Head and Neck Squamous Cell Carcinoma in Thai Patients. Thai J Surg [Internet]. 2012 Sep. 28 [cited 2022 Oct. 7];33(3). Available from: https://he02.tci-thaijo.org/index.php/ThaiJSurg/article/view/226886

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