Thymoglobuline (ATG-r) Induction in Immunological High Risk Kidney Transplantation

Authors

  • Sopon Jirasiritham Division of Vascular and Transplantation, Department of Surgery, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • Surasak Kantachuvejsiri Division of Nephrology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • Vasant Sumethkul Division of Nephrology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • Viroon Mavichak Renal Unit, Pra Ram 9 Hospital, Bangkok, Thailand
  • North Techawathanawanna Renal Unit, Pra Ram 9 Hospital, Bangkok, Thailand
  • Rungrote Khunprakant Renal Unit, Pra Ram 9 Hospital, Bangkok, Thailand
  • Siriwan Jirasiritham Department of Anesthesiology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
  • Suchin Worawichawong Department of Pathology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

Keywords:

Thymoglobulin, high risk kidney transplantation, CMV infection

Abstract

Objective: To study the efficacy of the thymoglobulin (ATG-r) as an induction therapy for prevention of
rejection in high risk kidney transplantation
Materials and Methods: All high risk kidney transplantation patients during 2008-2010 who received
thymoglobulin (ATG-r) as induction therapy were reviewed. The primary end-points was the incidence of biopsy
proved acute rejection (BPAR) and the secondary end-points were adverse events relating to the use of
thymoglobulin including the infectious morbidity, the graft and patient survival rate .
Results: The rate of acute rejection was 7.3%. The rate of CMV infection was 14.6%. There was one
death (3.7%) due to severe bacterial infection. One-year graft and patient survival rate were 96.3% and 96.3%
respectively.
Conclusion: Thymoglobulin (ATG-r) was an effective induction therapy in high risk kidney transplantation
with the results comparable to the normal risk kidney transplantation. The complication of CMV infection could
be effectively treated by preemptive therapy to prevent CMV disease.

References

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2. Willoughby LM, Schnitzler MA, Brennan DC, et al. Early
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3. Brennan DC, Daller JA, Lake KD , et al . Rabbit antithymocyte
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4. Hardinger KL, Brennan DC, Schnitzler MA, et al . Rabbit
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6. Strippoli GF, Hodson EM, Jones C, et al . Preemptive treatment
for cytomegalovirus viremia to prevent cytomegalovirus
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vol33no4

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Published

2012-12-28

How to Cite

1.
Jirasiritham S, Kantachuvejsiri S, Sumethkul V, Mavichak V, Techawathanawanna N, Khunprakant R, Jirasiritham S, Worawichawong S. Thymoglobuline (ATG-r) Induction in Immunological High Risk Kidney Transplantation. Thai J Surg [Internet]. 2012 Dec. 28 [cited 2024 Nov. 22];33(4). Available from: https://he02.tci-thaijo.org/index.php/ThaiJSurg/article/view/227147

Issue

Vol. 33 No. 4 (2012): October - December

Section

Original Articles

License

Articles must be contributed solely to The Thai Journal of Surgery and when published become the property of the Royal College of Surgeons of Thailand. The Royal College of Surgeons of Thailand reserves copyright on all published materials and such materials may not be reproduced in any form without the written permission.