Thymoglobuline (ATG-r) Induction in Immunological High Risk Kidney Transplantation
Keywords:
Thymoglobulin, high risk kidney transplantation, CMV infectionAbstract
Objective: To study the efficacy of the thymoglobulin (ATG-r) as an induction therapy for prevention ofrejection in high risk kidney transplantation
Materials and Methods: All high risk kidney transplantation patients during 2008-2010 who received
thymoglobulin (ATG-r) as induction therapy were reviewed. The primary end-points was the incidence of biopsy
proved acute rejection (BPAR) and the secondary end-points were adverse events relating to the use of
thymoglobulin including the infectious morbidity, the graft and patient survival rate .
Results: The rate of acute rejection was 7.3%. The rate of CMV infection was 14.6%. There was one
death (3.7%) due to severe bacterial infection. One-year graft and patient survival rate were 96.3% and 96.3%
respectively.
Conclusion: Thymoglobulin (ATG-r) was an effective induction therapy in high risk kidney transplantation
with the results comparable to the normal risk kidney transplantation. The complication of CMV infection could
be effectively treated by preemptive therapy to prevent CMV disease.
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