Effects of Waiting Time and Biopsy Methods on Invasive Breast Cancer Survival
Keywords:
biopsy, breast cancer, waiting time, survivalAbstract
Objective: To examine the effects of the waiting time from biopsy to definitive surgery and the type ofbiopsy method on invasive breast cancer survival.
Patients and Methods: Three hundred and fifty-nine medical records from women who were diagnosed
with unilateral, non-metastatic invasive breast cancer between January 2000 and December 2001 were reviewed.
Cox regression analysis was used to determine the relationship between the waiting time, biopsy method, and
overall as well as disease-free survival, adjusted for other clinical and pathological factors.
Results: Patients were 50 years old on the average; 80% had stage I-II disease. The median waiting time
was 1.9 weeks. Fifty-five percent of patients underwent definitive surgery within two weeks of biopsy. Excisional
biopsy or frozen section diagnosis was performed in 74% of patients. The 5-year overall survival was 90% and
5-year disease-free survival was 79%. There was no significant association between the waiting time and overall
survival or disease-free survival after adjusting for tumor stage. Core or fine needle biopsy was significantly
associated with better disease-free survival, but not with overall survival, for patients with stage I-II breast
cancer.
Conclusion: The present study suggested that waiting time had minimal effects on breast cancer survival
whereas core- or fine-needle biopsy was associated with a better disease-free survival as compared with open
biopsy.
References
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patients. Jpn J Surg 1989;19:679-83.
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patients with breast cancer by use of reverse transcriptase
polymerase reaction. Surgery 1995;117:96-101.
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effluent venous blood breast cancer surgery. Br J Cancer
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79:858-64.
16. King TA, Hayes DH, Cederbom GJ, et al. Biopsy technique
has no impact on local recurrence after breast-conserving
therapy. Breast J 2001;7:19-24.
17. Chen AM, Haffty BG, Lee CH. Local recurrence of breast
cancer after breast conservation therapy in patients
examined by means of stereotactic core-needle biopsy.
Radiology 2002;225:707-12.
18. Fitzal F, Sporn EP, Draxler W, et al. Preoperative core needle
biopsy does not increase local recurrence rate in breast
cancer patients. Breast Cancer Res Treat 2006;97:9-15.
19. Liotta L, Kleineman J, Saidel GM. The significance of hematogenous
tumor cell clumps in the metastatic process. Cancer
Res 1976;36:889-94.
20. Nishizaki T, Matsumata T, Kanematsu T, Yasunaga C,
Sugimachi K. Surgical manipulation of VX2 carcinoma in the
rabbit liver evokes enhance ment of metastasis. J Surg Res
1990;49:92-7.
21. Hu XC, Loo WTY, Chow WCL. Surgery-related shedding of
breast cancer cells as determined by RT-PCR assay. J Surg
Oncol 2003;82:228-32.
22. Cristofanilli M, Budd GT, Ellis MJ, et al. Circulating tumor cells,
disease progression, and survival in metastatic breast cancer.
N Engl J Med 2004;351:781-91.
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therapeutic strategies. New York: Informa Healthcare; 2007.
p. 103-45.
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breast cancer after skin sparing mastectomy following core
needle biopsy: case reports and review of the literature.
Breast J 2006;12:194-8.
(commentary). Lancet 1999;353:1112-3.
2. Richards MA, Westcombe AM, Love SB, Littlejohns P, Ramirez
AJ. Influence of delay on survival in patients with breast
cancer: a systematic review. Lancet 1999;353:1119-26.
3. Chung KP, Lai KS, Cheng SH, et al. Organization-based
performance measures of cancer care quality: core
measure development for breast cancer in Taiwan. Eur J
Cancer Care 2008;17:5-18.
4. Saint-Jacques N, Younis T, Dewar R, Rayson D. Wait times for
breast cancer care. Br J Cancer 2007;96:162-8.
5. Sainsbury R, Johnston C, Haward B. Effect on survival of
delays in referral of patients with breast cancer symptoms:
a retrospective analysis. Lancet 1999;353:1132-5.
6. Raabe NK, Fossaa SD. Primary invasive breast carcinoma in
Oslo 1980-1989. Incidence and delay. Acta Oncol 1996;35:9-
15.
7. Fisher ER, Sass R, Fisher B. Biologic considerations regarding
the one and two step procedures in the management of
patients with invasive carcinoma of the breast. Surg Gynecol
Obstet 1985;161:245-9.
8. Bertario L, Reduzzi D, Piromalli D, Piva L, Di Pietro S. Outpatient
biopsy of breast cancer. Influence on survival. Ann Surg
1985;201:64-7.
9. Urban JA. The case against delayed operation for breast
cancer. CA Cancer J Clin 1971;21:132-3.
10. Hattori T, Niimoto M, Nakano A, Itagaki E, Inoue K, Morimoto
T. Biopsy of the breast. Jpn J Surg 1980;10:270-6.
11. Toi M, Nakamura T, Wada T, et al. The acceptable delay
between biopsy and radical mastectomy in breast cancer
patients. Jpn J Surg 1989;19:679-83.
12. Brown DC, Purushotham AD, Birnie GD, George WD.
Detection of intraoperative tumor cell dissemination in
patients with breast cancer by use of reverse transcriptase
polymerase reaction. Surgery 1995;117:96-101.
13. Choy A, McCulloch P. Induction of tumor cell shedding into
effluent venous blood breast cancer surgery. Br J Cancer
1996;73:79-82.
14. Greene FL, Page DL, Fleming ID, Fritz A, Balch CM, Haller DG,
Morrow M, eds. AJCC cancer staging manual. 6th ed. New
York: Springer-Verlag, 2002.
15. Richards MA, Smith P, Ramirez AJ, Fentiman IS, Rubens RD.
The influence on survival of delay in the presentation and
treatment of symptomatic breast cancer. Br J Cancer 1999;
79:858-64.
16. King TA, Hayes DH, Cederbom GJ, et al. Biopsy technique
has no impact on local recurrence after breast-conserving
therapy. Breast J 2001;7:19-24.
17. Chen AM, Haffty BG, Lee CH. Local recurrence of breast
cancer after breast conservation therapy in patients
examined by means of stereotactic core-needle biopsy.
Radiology 2002;225:707-12.
18. Fitzal F, Sporn EP, Draxler W, et al. Preoperative core needle
biopsy does not increase local recurrence rate in breast
cancer patients. Breast Cancer Res Treat 2006;97:9-15.
19. Liotta L, Kleineman J, Saidel GM. The significance of hematogenous
tumor cell clumps in the metastatic process. Cancer
Res 1976;36:889-94.
20. Nishizaki T, Matsumata T, Kanematsu T, Yasunaga C,
Sugimachi K. Surgical manipulation of VX2 carcinoma in the
rabbit liver evokes enhance ment of metastasis. J Surg Res
1990;49:92-7.
21. Hu XC, Loo WTY, Chow WCL. Surgery-related shedding of
breast cancer cells as determined by RT-PCR assay. J Surg
Oncol 2003;82:228-32.
22. Cristofanilli M, Budd GT, Ellis MJ, et al. Circulating tumor cells,
disease progression, and survival in metastatic breast cancer.
N Engl J Med 2004;351:781-91.
23. Lyman GH, Burstein HJ. Breast cancer: translational
therapeutic strategies. New York: Informa Healthcare; 2007.
p. 103-45.
24. Uriburu JL, Vuoto HD, Cogorno L, et al. Local recurrence of
breast cancer after skin sparing mastectomy following core
needle biopsy: case reports and review of the literature.
Breast J 2006;12:194-8.
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Published
2009-12-30
How to Cite
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Hiranyatheb P, Kongdan Y, Lertsithichai P. Effects of Waiting Time and Biopsy Methods on Invasive Breast Cancer Survival. Thai J Surg [Internet]. 2009 Dec. 30 [cited 2024 Apr. 26];30(3-4). Available from: https://he02.tci-thaijo.org/index.php/ThaiJSurg/article/view/227810
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