Upper Gastrointestinal Endoscopy Findings in Patients Presenting with Dyspepsia
Keywords:upper gastrointestinal endoscopy, dyspepsia, H. pylori
AbstractObjective: To determine the prevalence of important upper gastrointestinal (UGI) lesions in patients
with dyspepsia and to determine the associated risk factors.
Methods: A prospective cohort study on dyspeptic patients undergoing UGI endoscopy during the
period between May 2006 and October 2008 was conducted. A questionnaire was administered to all patients
who consented to participate in the study. Endoscopic findings were defined as important if lesions seen were
gastric or duodenal ulcers, moderate to severe gastritis, severe esophagitis, adenomatous polyps or cancer.
Histological examination results were obtained for patients who also underwent endoscopic biopsy.
Results: A total of 291 dyspeptic patients were enrolled. Only 19% (54/291) of patients had important
endoscopic lesions. No clinical findings including age and alarm symptoms were related to important
endoscopic lesions. In 132 patients, 23% (30/132) of the endoscopic biopsies showed evidence of H. pylori
infection. In patients with endoscope biopsy results, H. pylori infection was not associated with important
Conclusion: Dyspeptic patients had a low prevalence of important endoscopic lesions. The presence of
these lesions could not be reliably predicted using clinical data and H. pylori infection status. Empirical antiacid
therapy was recommended as the initial screening therapeutic test prior to endoscopic evaluation for most
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