Mono- or Poly- Antimicrobial Prophylaxis in Colorectal Surgery

Authors

  • Varut Lohsirwat Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
  • Atthaphorn Trakarnsanga Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
  • Thawatchai Akaraviputh Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
  • Vitoon Chinswangwatanakul Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
  • Darin Lohsiriwat Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Abstract

Objective: The use of prophylactic antibiotics in colorectal surgery is well established. Type of antibiotics, however; varies significantly among surgeons. The aim of this study was to determine whether mono-antimicrobial regimen is as effective as poly-antimicrobial regimen in the prevention of surgical wound infections following elective colorectal cancer surgery.

Materials and Methods:  The medical records of 56 patients with colorectal cancer undergoing elective oncological resection from January 2004 to September 2006 at Siriraj Hospital, Bangkok, were retrospectively reviewed. Patients were divided into two groups according to the regimen of prophylactic intravenous antibiotics; group A: monotherapy (cefminox-Meicelin) and group B: polytherapy (ceftriaxone plus metronidazole). The duration of antibiotics administration was up to 24 hours in colonic surgery and up to 3 days in rectal surgery. Patient characteristics and rate of wound infection within 30 days after the operation were compared between the two groups.

Results: This study included 25 males and 31 females, with a mean age of 63 years (range 27-:86). There were 18 patients in group A and 38 patients in group B. There was no significant difference in patient characteristics between the two groups. Overall rate of wound infection was 14.35%. Rate of wound infection was not significantly different between the two groups (group A 11.1 % vs group B 15.8%, P = 1.00). No adverse drug reaction was found in this study. 

Conclusions: Based on this study, there was no significant difference in the rate of wound infection

following elective colorectal cancer surgery with mono-antimicrobial regimen, compared to that with poly antimicrobial regimen. Thus, single drug regimen could be a feasible alternative in antibiotic prophylaxis for the prevention of wound infection following elective lower gastrointestinal tract surgery.

References

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Published

2008-07-31

How to Cite

1.
Lohsirwat V, Trakarnsanga A, Akaraviputh T, Chinswangwatanakul V, Lohsiriwat D. Mono- or Poly- Antimicrobial Prophylaxis in Colorectal Surgery. Thai J Surg [Internet]. 2008 Jul. 31 [cited 2024 Dec. 23];29(3):77-80. Available from: https://he02.tci-thaijo.org/index.php/ThaiJSurg/article/view/241033

Issue

Vol. 29 No. 3 (2008): July - September

Section

Original Articles

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Articles must be contributed solely to The Thai Journal of Surgery and when published become the property of the Royal College of Surgeons of Thailand. The Royal College of Surgeons of Thailand reserves copyright on all published materials and such materials may not be reproduced in any form without the written permission.