Increase of the Expression of Receptors of Steroid Hormones in Patients with a Partial Androgen Deficiency of Aging Men (PADAM)

Authors

  • Alexander V. Pechersky Department of Surgery, St, Petersburg Medical Academy of Post-Graduate Studies, St, Petersburg, Russia
  • Vladimir F. Semiglazov Surgical Department, N.N. Petrov Scientific-Research Institute of Oncology, St. Petersburg, Russia
  • Boris K. Komyakov Department of Urology. St. Petersburg State Medical Academy of I.I. Mechnikov, St, Petersburg, Russia
  • Bakhman G. Guliev Department of Urology, Municipal Multi-Profile Hospital No 2, St. Petersburg, Russia
  • Andrey I. Gorelov Urology Course, St, Petersburg State University, St. Petersburg, Russia
  • Andrey I. Novikov Department of Urology. St. Petersburg State Medical Academy of I.I. Mechnikov, St, Petersburg, Russia
  • Viktor I. Pechersky Problem Scientific-Research Laboratory, P.F, Lestgaft State Academy of Physical Education, St, Petersburg, Russia
  • Nikolay N. Simonov Surgical Department, N.N. Petrov Scientific-Research Institute of Oncology, St. Petersburg, Russia
  • Alexey V. Gulyaev Surgical Department, N.N. Petrov Scientific-Research Institute of Oncology, St. Petersburg, Russia
  • Igor A. Samusenko Department of Pathological Anatomy, St, Petersburg State Medical Academy of ll, Mechnikov, St, Petersburg
  • Maxim S. Vonsky Laboratory of Genome Structural Organization, Institute of Cytology of the Russian Academy of Sciences, S1, Petersburg, Russia
  • Alexey G. Mittenberg Laboratory of Regulation of Gene Expression, Institute of Cytology, Russian Academy of Sciences
  • Oleg B. Loran Department of Urology, Russian Medical Academy of Post-Graduate Studies, Moscow, Russia

Abstract

Objectives: To study the disruption of the normal development cycle of cells with androgen receptors by partial androgen deficiency of aging men (PADAM).

Materials and Methods: In the current study, 15 patients were held under observation (5 with prostate cancer, 5 with bladder cancer and 5 with rectal cancer).

Results: The levels of testosterone in the tissues of the peritumorous zone of the prostate as well as in the tumorous tissue in patients with cancer of the prostate, bladder and rectum were higher than analogous indices in the blood serum. The indices of the histochemical score of androgen (AR) in the peritumorous zone among patients with prostate cancer were higher than the analogous indices of the control group; Upon research of the peritumorous zone among patients observed groups, expressions of ER, PR, bcl-2, Ki67 and p53 were detected.

Conclusions: The results of this study suggest the conclusion that production of testosterone by a whole set of tumors and tissues of the peritumorous zone, which is accompanied by increased proliferative activity and disturbance of the regulation of the cell cycle, is caused by PADAM. The given changes are directed at compensating for testicular deficiency.

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Published

2006-06-30

How to Cite

1.
Pechersky AV, Semiglazov VF, Komyakov BK, Guliev BG, Gorelov AI, Novikov AI, Pechersky VI, Simonov NN, Gulyaev AV, Samusenko IA, Vonsky MS, Mittenberg AG, Loran OB. Increase of the Expression of Receptors of Steroid Hormones in Patients with a Partial Androgen Deficiency of Aging Men (PADAM). Thai J Surg [Internet]. 2006 Jun. 30 [cited 2024 Mar. 29];27(2):93-100. Available from: https://he02.tci-thaijo.org/index.php/ThaiJSurg/article/view/242039

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