Factor V Leiden and Prothrombin Gene Mutation in Deep Vein Thrombosis

Authors

  • Sarawut Thanawut Department of Surgery, Siriraj Hospital and Faculty of Medicine, Mahidol University, Bangkok
  • Yongyut Sirivatanauksorn Department of Surgery, Siriraj Hospital and Faculty of Medicine, Mahidol University, Bangkok
  • Chanin Limwongs Division of Molecular Genetics, Department of Medicine, Siriraj Hospital and Faculty of Medicine, Mahidol University, Bangkok

Keywords:

factor V Leiden, prothrombin G20210A gene mutation

Abstract

Objectives: To study the prevalence of genetic risk variation in factor V gene (G1691A Leiden mutation) and prothrombin gene (G20210A)

Materials and Methods: Polymerase chain reaction techniques were performed in 50 healthy Thais and 48 patients with deep vein thrombosis.

Results: The prevalence of both factor V Leiden and prothrombin G20210A gene mutation in a control group was zero. Of 48 patients with DV'T, the disease was located in the lower extremities, none was a carrier of factor V Leiden or the prothrombin gene mutation. Our finding confirms the previous study by Angchaisuksiri et al who found a very low prevalence of this mutation in Thai patients with DVT.

Conclusion: The screening for factor V Leiden and Prothrombin gene mutation is not beneficial and may not be cost-effective in Thai patients with DVT.

References

1. Anderson FA, Wheeler HB, Goldberg RJ, et al. A population based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT study. Arch Int Med 1991; 151:933-8.

2. Atichartakarn V, Songsiridej N, Jootar S. Incidence and risk factors of deep vein thrombosis among Thai patients: their implications on patients' management. J Med Assoc Thai 1998;71:231-7.

3. Lane DA, Mannucci PM, Bauer KA, et al. Inherited thrombophilia: part 1. Thromb Haemo 1996; 76:651-62.

4. Dahlback B, Carisson M, Stvensson PJ, Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulation response to activated protein C: prediction of a cofactor to activated protein C. Proc NatSci USA 1993; 90: 1004-8.

5. Poort RS, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996;88: 3698-703.

6. Svensson PJ, Dahlback B. Resistance to activated protein c as a basis for venous thrombosis. N Engl J Med 1994;330:517-22.

7. Rosendaal FR, Koster T, Vansenbroucke J, Reitema PH. High risk of thrombosis in patients homozygous for factor V Leiden (Activated protein C resistance). Blood 1995;85: 1504-8.

8. Prayoonwiwat W, Arnutti P, Hiyoshi M. Detection of faction V Leiden in Thai patient with venous thrombosis. Asian Pac J All Immu 2000; 18: 105-8.

9. Angchaisuksiri P, Pingsuthiwong S, Arychai K. Prevalence of G 1691A mutation in the factor V gene (factor V Leiden) and the G20210A prothrombin gene mutation in the Thai population. Am J Hemat 2000; 65: 119-22.

10. Meyer G, Emmerich J, Fiessinger JN. Factor V Leiden and II 20210A in patients with symptomatic pulmonary embolism and deep vein thrombosis. Am J Med 2001; 110: 12-5.

11. He'zard N, Cornillet P, Droulle C, Gillot L, Potron G, Nguyen P. Factor V Leiden : detection in whole blood by ASA PCR using an additional mismatch in antepenultimate position. Throm Res 1997; 88: 59-66.

12. Poort RS, Bertina RM, Vos HL. Rapid detection of the prothrombin 20210a variation by allele specific PCR. Thromb Haemost 1997; 78:1157-8.

13. Pepe G, Rickarde O, Abbate R. Prevalence of factor V Leiden mutation in non-European populations. Thromb Haemo 1997; 77:329-31.

14. Bertina RM. Molecular risk factors for thrombosis. Thromb Haem 1999; 82: 601-9.

15. Rees DC, Cox M, Clegg JB. World distribution of factor V Leiden. Lancet 1995; 346:1133-4.

16. Reber G, Perrier A, Perneger T, Bounameaux H. Prevalence of factor V Leiden and prothrombin G20210A mutation in unselected patients with venous thrombolism. Brit J Haematol 2000; 110:125-9.

17. Martinelli I, Bucciarelli P, Mannucci PM. The risk of venous thromboembolism in family members with mutation in the genes of factor V or prothrombin or both, Brit J Haematol 2000;111:1223-9.

18. Rosendaal FR. Risk factors for venous thrombotic disease. Thromb Haemo 1999; 82: 6109.

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Published

2006-03-31

How to Cite

1.
Thanawut S, Sirivatanauksorn Y, Limwongs C. Factor V Leiden and Prothrombin Gene Mutation in Deep Vein Thrombosis. Thai J Surg [Internet]. 2006 Mar. 31 [cited 2024 Apr. 19];27(1):11-4. Available from: https://he02.tci-thaijo.org/index.php/ThaiJSurg/article/view/242045

Issue

Vol. 27 No. 1 (2006): January - March

Section

Original Articles

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Articles must be contributed solely to The Thai Journal of Surgery and when published become the property of the Royal College of Surgeons of Thailand. The Royal College of Surgeons of Thailand reserves copyright on all published materials and such materials may not be reproduced in any form without the written permission.