Factor V Leiden and Prothrombin Gene Mutation in Deep Vein Thrombosis

Authors

  • Sarawut Thanawut Department of Surgery, Siriraj Hospital and Faculty of Medicine, Mahidol University, Bangkok
  • Yongyut Sirivatanauksorn Department of Surgery, Siriraj Hospital and Faculty of Medicine, Mahidol University, Bangkok
  • Chanin Limwongs Division of Molecular Genetics, Department of Medicine, Siriraj Hospital and Faculty of Medicine, Mahidol University, Bangkok

Keywords:

factor V Leiden, prothrombin G20210A gene mutation

Abstract

Objectives: To study the prevalence of genetic risk variation in factor V gene (G1691A Leiden mutation) and prothrombin gene (G20210A)

Materials and Methods: Polymerase chain reaction techniques were performed in 50 healthy Thais and 48 patients with deep vein thrombosis.

Results: The prevalence of both factor V Leiden and prothrombin G20210A gene mutation in a control group was zero. Of 48 patients with DV'T, the disease was located in the lower extremities, none was a carrier of factor V Leiden or the prothrombin gene mutation. Our finding confirms the previous study by Angchaisuksiri et al who found a very low prevalence of this mutation in Thai patients with DVT.

Conclusion: The screening for factor V Leiden and Prothrombin gene mutation is not beneficial and may not be cost-effective in Thai patients with DVT.

References

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Published

2006-03-31

How to Cite

1.
Thanawut S, Sirivatanauksorn Y, Limwongs C. Factor V Leiden and Prothrombin Gene Mutation in Deep Vein Thrombosis. Thai J Surg [Internet]. 2006 Mar. 31 [cited 2024 Nov. 23];27(1):11-4. Available from: https://he02.tci-thaijo.org/index.php/ThaiJSurg/article/view/242045

Issue

Vol. 27 No. 1 (2006): January - March

Section

Original Articles

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Articles must be contributed solely to The Thai Journal of Surgery and when published become the property of the Royal College of Surgeons of Thailand. The Royal College of Surgeons of Thailand reserves copyright on all published materials and such materials may not be reproduced in any form without the written permission.