The Effect of Local Infiltration of NSAIDs on Surgical Wound Healing in Rats
Abstract
Objective: This study was designed to determine the effect of local infiltration of NSAIDs on the tensile strength of surgical wounds.
Materials and Methods: In the experimental study, twelve male Sprague Dawley rats were divided into two groups. Under sterile technique, they were anesthetized with pentobarbital intraperitoneally (30 mg/kg bw). A linear wound was made on the midline of the abdomen. Bupivacaine (1 mg/kg bw) and normal saline was locally infiltrated to rats in group I and bupivacaine (1 mg/kg bw) with parecoxib was locally infiltrated to those in group 2. On the 7th postoperative day, the wounds were totally stitched off and tensile strength was measured by computerized tensinometer.
Results: This study revealed no differences in the measurement of tensile strength between parecoxib and control group (P value = 0.394).
Conclusion: Local infiltration of NSAIDs (parecoxib) did not impair wound healing.
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