Synchronous Adenocarcinomas of Jejunum: A Case Report

Authors

  • Teerawut Rakchob Department of Surgery, Buriram Hospital, Buriram

Keywords:

Adenocarcinoma, Jejunum, Synchronous

Abstract

Small bowel adenocarcinoma is a rare cancer. The standard treatment is surgical resection with free surgical margins. We report a case of synchronous, multiple adenocarcinoma of jejunum, in which curative resection was performed and adjuvant chemotherapy after surgery was given. The patient was a 49-year-old man who presented with abdominal pain for one month. Abdominal computer tomography (CT) revealed a segment of irregularly-shaped proximal jejunum with mucosal thickening, suggestive of small bowel carcinoma. The patient underwent proximal jejunal resection with negative resection margins. Pathological examination showed poorly differentiated adenocarcinoma at two separate locations, with invasion to the serosa as well as angiolymphatic invasion. There was no regional lymph node metastasis. The patient was received adjuvant treatment with Fluoropyrimidine based chemotherapy. After a follow up of 8 months, there was no evidence of tumor recurrence or metastasis. Synchronous small bowel carcinoma is a rare condition. Curative treatment is primarily a segmental resection with negative margins, with adjuvant chemotherapy for improved outcome. The diagnosis requires a high index of suspicion.

References

Aparicio T, Zaanan A, Svrcek M, et al. Small bowel adenocarcinoma: epidemiology, risk factors, diagnosis and treatment. Dig Liver Dis 2014;46:97-104.

Bauer RL, Palmer ML, Bauer AM, et al Adenocarcinoma of the small intestine: 21-year review of diagnosis, treatment, and prognosis. Ann Surg Oncol 1994;1:183-8.

Bennett CM, Coleman HG, Veal PG, et al. Lifestyle factors and small intestine adenocarcinoma risk: A systematic review and meta-analysis. Cancer Epidemiol 2015;39:265-73.

Dabaja BS, Suki D, Pro B, et al. Adenocarcinoma of the small bowel: presentation, prognostic factors, and outcome of 217 patients. Cancer 2004;101:518-26.

Delaunoit T, Neczyporenko F, Limburg PJ, Erlichman C. Small bowel adenocarcinoma: a rare but aggressive disease. Clin Colorectal Cancer 2004;4:241-8.

Ye X, Zhang G, Chen H, Li Y. Meta-analysis of postoperative adjuvant therapy for small bowel adenocarcinoma. PLoS One. 2018;13:e0200204.

Ren PT, Fu H. Primary segmental and multiple adenocarcinomas of the small bowel. Intern Med 2012;51:877-80.

Candia-de la Rosa RF, Sampayo-Candia R, Breton-Toral JC, et al. [Primary adenocarcinoma of the terminal ileum, synchronous]. Cir Cir 2015;83:232-7.

Nazari M, Lee A, Rosenblum J, et al. Eighteen month interval growth of terminal ileal primary adenocarcinoma: a consideration for current screening guidelines. Case Rep Gastroenterol 2017;11:780-5.

Chen EY, Vaccaro GM. Small bowel adenocarcinoma. Clin Colon Rectal Surg 2018;31:267-77.

Fedele S, Delvecchio A, De Giorgi C, et al. Small bowel adenocarcinoma in a patient with a 5-year history of untreated Crohn's disease: A case report. G Chir 2018;39:383-7.

Partridge SK, Hodin RA. Small bowel adenocarcinoma at a strictureplasty site in a patient with Crohn's disease: Report of a case. Dis Colon Rectum 2004;47:778-81.

Tirath A, Christophi GP, Fraum TJ, et al. Mucinous small bowel adenocarcinoma mimicking change to internal penetrating phenotype in well-controlled Crohn's disease. Am J Gastroenterol 2018;113:1732-3.

Rompteaux P, Gagniere J, Gornet JM, et al. Resection of small bowel adenocarcinoma metastases: Results of the ARCAD-NADEGE cohort study. Eur J Surg Oncol 2019;45:331-5.

Cavalla C, Oppliger F, Schiappacasse G, et al. Multiple synchronous adenocarcinomas of the small bowel in a young patient: A case report. Int J Surg Case Rep 2018;42:250-3.

Sharma M, Singh R, Grover AS. Peutz-jeghers syndrome with synchronous adenocarcinoma arising from ileal polyps. Indian J Surg 2015;77(Suppl 1):100-2.

Sammartino P, Sibio S, Di Giorgio A, et al. Two synchronous adenocarcinomas of the small bowel in a patient with undiagnosed Crohn's disease of the terminal ileum. Int J Colorectal Dis 2006;21:388-91.

Benson AB, Venook AP, Al-Hawary MM, et al. Small bowel adenocarcinoma, version 1.2020, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw 2019;17:1109-33.

Zhang S, Yuan W, Zhang J, et al. Clinicopathological features, surgical treatments, and survival outcomes of patients with small bowel adenocarcinoma. Medicine (Baltimore). 2017;96:e7713.

Wilhelm A, Muller SA, Steffen T, et al. Patients with adenocarcinoma of the small intestine with 9 or more regional lymph nodes retrieved have a higher rate of positive lymph nodes and improved survival. J Gastrointest Surg 2016;20:401-10.

Wu S, Chen JN, Zhang QW, et al. A new metastatic lymph node classification-based survival predicting model in patients with small bowel adenocarcinoma: A derivation and validation study. EBioMedicine 2018;32:134-41.

Thiessen M, Lee-Ying RM, Monzon JG, Tang PA. An examination of lymph node sampling as a predictor of survival in resected node-negative small bowel adenocarcinoma: A SEER database analysis. J Gastrointest Cancer 2020;51:280-8.

Horimatsu T, Funakoshi T, Muto M. [I. Chemotherapy for Small Bowel Adenocarcinoma]. Gan To Kagaku Ryoho 2018;45:1589-93.

Kitahara H, Honma Y, Ueno M, et al. Randomized phase III trial of post-operative chemotherapy for patients with stage I/II/III small bowel adenocarcinoma (JCOG1502C, J-BALLAD). Jpn J Clin Oncol 2019;49:287-90.

Stamopoulos P, Machairas N, Kykalos S, et al. Intraluminal rectal cancer metastasis to the small bowel: An extremely rare case report. Mol Clin Oncol 2017;7:553-6.

De Castro CA, Dockerty MB, Mayo CW. Metastatic tumors of the small intestines. Surg Gynecol Obstet 1957;105:159-65.

Zhu QQ, Zhu WR, Wu JT, et al. Comparative study of intestinal tuberculosis and primary small intestinal lymphoma. World J Gastroenterol 2014;20:4446-52.

2015 H-BCR. Thai Cancer Base, National Cancer Institute [Internet]. 2015.

Rongviriyapanich A. Adenocarcinoma of jejunum. J Surg Case Rep 2018;2018(8):rjy234.

Downloads

Published

2021-03-30

How to Cite

1.
Rakchob T. Synchronous Adenocarcinomas of Jejunum: A Case Report. Thai J Surg [Internet]. 2021 Mar. 30 [cited 2024 Nov. 22];42(1):28-32. Available from: https://he02.tci-thaijo.org/index.php/ThaiJSurg/article/view/244122

Issue

Section

Case Reports