Prognosis and Clinical Outcome of Papillary Carcinoma of The Breast at A Tertiary Care Hospital
Keywords:
Papillary breast cancer, Papillary lesions, PrognosisAbstract
Objective: To determine the clinical, pathologic and prognostic features of papillary breast cancer seen at a tertiary care hospital.
Materials and Methods: A retrospective review of medical charts of patients seen during the period between January 2010 to December 2013 was performed.
Results: There were 86 patients with papillary breast cancer who underwent surgery during the period. This constituted 3% of all breast cancer patients who underwent surgery during the same period. The majority (74%) were invasive papillary cancers. Most patients were menopausal with an average age of 61 years. Most cancers were hormone-receptor positive, and HER2 negative. The average tumor size was 2 cm and only 10% had axillary node metastasis. The majority (69%) underwent mastectomy and most (60%) had hormonal therapy as the only systemic adjuvant. Under a median follow-up of 22 months (range; 1 to 53 months), there were no recurrences or deaths observed in the series.
Conclusion: Papillary breast cancer has a very good prognosis and treatment should be minimized in a similar way as a mucinous carcinoma.
References
2. Fisher ER, Palekar AS, Redmond C, et al. Pathologic findings from the National Surgical Adjuvant Breast Project (protocol no. 4) VI. Invasive papillary cancer. Am J Clin Pathol 1980;73:313-22.
3. Gentile A, Becette V. Invasive papillary and pseudopapillary (micropapillary) carcinoma of the breast. Arch Anat Cytol Patho 1996;44:225-30.
4. Pal SK, Lau SK, Kruper L, et al. Papillary carcinoma of the breast: an overview. Breast Cancer Res Treat 2010;122:637-45.
5. Mulligan AM, O’Malley FP. Papillary lesions of the breast: a review. Adv Anat Pathol 2007;14:108-19.
6. Collins LC, Schnitt SJ. Papillary lesions of the breast: selected diagnostic and management issues. Histopathology 2008;52: 20-9.
7. Ueng SH, Mezzetti T, Tavassoli FA. Papillary neoplasms of the breast: a review. Arch Pathol Lab Med 2009;133:893-907.
8. Page DL, Salhany KE, Jensen RA, Dupont WD. Subsequent breast carcinoma risk after biopsy with atypia in a breast papilloma. Cancer 1996;78:258-66.
9. Esposito NN, Dabbs DJ, Bhargava R. Are encapsulated papillary carcinomas of the breast in situ or invasive? A basement membrane study of 27 cases. Am J Clin Pathol 2009;131:228-42.
10. Maluf HM, Koerner FC. Solid papillary carcinoma of the breast. A form of intraductal carcinoma with endocrine differentiation frequently associated with mucinous carcinoma. Am J Surg Pathol 1995;19:1237-44.
11. Nassar H, Qureshi H, Volkanadsay N, Visscher D. Clinicopathologic analysis of solid papillary carcinoma of the breast and associated invasive carcinomas. Am J Surg Pathol 2006;30:501-7.
12. Koerner F. Papilloma and papillary carcinoma. Semin Diag Pathol 2010;27:13-30.
13. Jakate K, De Brot M, Goldberg F, et al. Papillary lesions of the breast: impact of breast pathology subspecialization on core biopsy and excision diagnoses. Am J Surg Pathol 2012;36:544-51.
14. Oh EJ, Koo JS, Kim JY, Jung WH. Correlation between solid papillary carcinoma and associated invasive carcinoma according to expression of WT1 and several MUCs. Pathol Res Pract 2014;210:953-8.
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