Rhabdomyolysis in Renal Transplant Patient Treated with Simvastatin and Cyclosporin: A Case Report

Authors

  • Supot Wudhikarn Division of Urology, Department of Surgery, Faculty of Medicine, Chiangmai University, Chiangmai., Thailand
  • Siwat Puriyapan Division of Urology, Department of Surgery, Faculty of Medicine, Chiangmai University, Chiangmai., Thailand
  • Dusit Lumlertkul Division of Nephrology, Department of Medicine, Faculty of Medicine, Chiangmai University, Chiangmai., Thailand

Abstract

             We describe a patient treated with com bination of cyclosporin and simvastatin who had to be hospitalized due to rhabdomyolysis. After cessation of treatment with simvastatin, intensive hydration and plasmaphoresis, the patient recovered in 2 weeks. While rhabdomyolysis had been described in several patients receiving the combination of lovastatin/ cyclosporin, so far only one case had been reported in patients treated with simvastatin / cyclosporin. Our case therefore suggested that this com bination may be more frequent than previously suspected. In patient treated with cyclosporin HIMG-CoA reductase inhibitor should be used cautiously.

References

1. Kasiske BL, Risk factors for accelerate atherosclerosis in renal transplant recipient. Am J Med 1988: 84:985.

2. Wing AJ, Brunner FP, Brynger H, et al. Cardiovascular related causes of death and the fate of patients with renovascular disease. Contr Nephrol 1984; 41:306.

3. Brown G, Albers J, Fisher LD, et al, Regression of coronary artery disease as a result of intensive lipid lowering therapy in men with high level of apolipoprotein B. N Engl J Med 1990;323:1289.

4. The lipid research clinic - coronary primary prevention trial result: ll the relationship of reduction incidence of coronary heart disease to cholesterol lowering. JAMA 1984; 251:365.

5. Castelao AM, Barbera MJ, Blanco A, et al. Lipid metabolic abnormalities after renal transplantation under cyclosporin and prednisolone immunosuppression. Transplant Proc 1992; 24:96.

6. Bittar AE. Ratchiffe PJ, Richardson AF, et al. The prevalence of hyperlipidemia in renal transplant recipients. Transplantation 1990; 50:987.

7. Maher VMG, Pappu A, Illingworth D, Thompson GR. Plasma mevalonate response in lovastatin related myopathy. Lancet 1989; i:1098.

8. Torbert JA. Efficacy and long term adverse effect pattern of lovastatin. Am J Cardiol 1988:62:28J-33J.

9. Corpier CL, Jones PH, Suki WN, et al. Rhabdomyolysis and renal injury with lovastatin use. JAMA 1988: 260:239-41.

10. Norman DJ, Ilingworth DR, Munsun JM, Hosenpud J. Myolysis and acute renal failure in heart transplant recipient receiving lovastatin, N Engl J Med 1988; 318:46-7.

11. Ayanian JZ, Fuchs CS, Stone RM. Lovastatin and rhabdomyolysis. Ann Intern Med 1988; 109:682.

12. Corpier CL, Jones PH, Suki WN, Lederer ED, Rhabdomyolysis and renal failure: 2 case reports. J Am Med Assoc 1988; 260:239-41.

13. Deslypere JP, Vermeulen A. Rhabdomyolysis and simvastatin. Am Intern Med 1991; 114:342.

14. Kogan AD, Orenstein S, Lovastatin - induced acute rhabdomyolysis. Postgrad Med J 1990; 66:294-6.

15. Pierce LR, Wysowski DK, Gross TP. Myopathy and rhabdomyolysis associated with lovastatin – gemfibrozil combination therapy. JAMA 1990; 264:715.

16. Grundy SM. HMG-CoA reductase inhibitors for treatment of hypercholesterolaemia. N Engl J Med 1988; 319:24-3.

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Published

1999-12-30

How to Cite

1.
Wudhikarn S, Puriyapan S, Lumlertkul D. Rhabdomyolysis in Renal Transplant Patient Treated with Simvastatin and Cyclosporin: A Case Report. Thai J Surg [Internet]. 1999 Dec. 30 [cited 2024 Dec. 23];20(4):137-8. Available from: https://he02.tci-thaijo.org/index.php/ThaiJSurg/article/view/247925