A DNA study in twin total colonic aganglionosis

Authors

  • Somboon Roekwibunsi Department of Surgery, King Chulalongkorn Memorial Hospital, Patumwan, Bangkok 10330, Thailand
  • Apivat Mutirangura Department of Anatomy, King Chulalongkorn Memorial Hospital, Patumwan, Bangkok 10330, Thailand
  • Young Poovorawan Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Patumwan, Bangkok 10330, Thailand
  • Bidhya Chandrakamol Department of Surgery, King Chulalongkorn Memorial Hospital, Patumwan, Bangkok 10330, Thailand

Keywords:

Total colonic aganglionosis

Abstract

                 Hirschsprung's disease is a frequent congenital malformation of unknown origin resulting in intestinal obstruction in neonates.  In the majority of the cases (80%), the aganglionic tract involves the rectum and the sigmoid colon while in 7% of cases it extends toward the entire colon (total aganglionosis) Recently, study of the pathogenesis of Hirschsprung's disease has concentrated on the genetic aspects. In the most recent studies, some groups were able to identify mutations of the RET protooncogene, thus suggesting a possible cause of  the disease.

                We report here a pair of twins, one member of which was effected by total colonic aganglionosis while the other was entirely normal. The monozygoticity was supported by using common DNA polymorphism short tandem repeat loci. Their parents' DNA polymorphism patterns were also studied.

References

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Published

1996-09-30

How to Cite

1.
Roekwibunsi S, Mutirangura A, Poovorawan Y, Chandrakamol B. A DNA study in twin total colonic aganglionosis. Thai J Surg [Internet]. 1996 Sep. 30 [cited 2024 Dec. 24];17(3):124-9. Available from: https://he02.tci-thaijo.org/index.php/ThaiJSurg/article/view/250121

Issue

Vol. 17 No. 3 (1996): July - September

Section

Original Articles

License

Articles must be contributed solely to The Thai Journal of Surgery and when published become the property of the Royal College of Surgeons of Thailand. The Royal College of Surgeons of Thailand reserves copyright on all published materials and such materials may not be reproduced in any form without the written permission.