Five-Year Survival and Prognostic Factors of Patients with Periampullary Carcinoma Who Underwent Pancreaticoduodenectomy

Authors

  • Setthabutr Eaupanitcharoen Department of Surgery Maharat Nakhon Ratchasima Hospital, Nakhon Ratchasima
  • Jitranun Narkmuenwai Department of Surgery Maharat Nakhon Ratchasima Hospital, Nakhon Ratchasima

Keywords:

Periampullary carcinoma, Pancreaticoduodenectomy, Survival rate

Abstract

Objective: Periampullary carcinomas are defined as tumors that arise within 2 cm of the major papilla. The pancreaticoduodenectomy is the standard curative treatment for these tumors. However, the long-term survival may vary due to many factors. This study aimed to identify prognostic factors and 5-year survival of periampullary carcinoma; and to evaluate the surgical outcomes of a pancreaticoduodenectomy.

Patients and Methods: We conducted a retrospective review of the medical records of patients with periampullary carcinoma who underwent pancreaticoduodenectomy from January 2010 to December 2014 in a tertiary hospital. Patient characteristics, perioperative data and pathological data were analyzed. Univariate and multivariate analysis of prognostic factors for survival was analyzed by the Cox proportional hazard model. The Kaplan-Meier survival curve was used to describe survival rate. The P-value less than 0.05 was considered as statistically significant.

Results: Of 61 patients (with a median age of 58 years), cancer of the ampulla of Vater was the most common tumor. The 3-year and 5-year overall survival rates were 52.5% and 34.4%, respectively. The 30-day postoperative mortality rate was 4.9%. Median overall survival time is 37.4 months. The independent prognostic factors were lymphovascular invasion (hazard ratio (HR): 9.10, 95% confidence interval (95% CI): 2.51 to 32.96, p = < 0.001) and moderate or poor tumor differentiation (HR: 2.28, 95% CI: 1.08 to 4.84, p = 0.03).

Conclusion: In this study, the 5-year overall survival rate was 34.4%. Poor prognostic factors of periampullary carcinoma after pancreaticoduodenectomy included the presence of lymphovascular invasion and poor to moderate tumor differentiation.

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Published

2022-08-19

How to Cite

1.
Eaupanitcharoen S, Narkmuenwai J. Five-Year Survival and Prognostic Factors of Patients with Periampullary Carcinoma Who Underwent Pancreaticoduodenectomy. Thai J Surg [Internet]. 2022 Aug. 19 [cited 2024 Oct. 13];43(2):70-7. Available from: https://he02.tci-thaijo.org/index.php/ThaiJSurg/article/view/254614

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