Current Surgical Role in Pediatric Gastroesophageal Reflux

Authors

  • Kittipot Uppakarn Division of Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla
  • Wison Laochareonsuk Division of Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla
  • Surasak Sangkhathat Division of Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla

Keywords:

Gastroesophageal reflux disease, Fundoplication, Esophagus

Abstract

Reflux of gastric content into the esophagus is a physiologic event that mostly disappears with body growth. However, infants and children with gastroesophageal reflux may develop pathologic consequences, from esophagitis, failure to thrive to airway problems. Such gastroesophageal reflux with a pathologic consequence is known as a gastroesophageal reflux disease (GERD). Certain groups of pediatric patients, including children with neurological impairment, congenital esophageal malformation or congenital diaphragmatic hernia, have increased risk of GERD and these groups of patients have poorer response to non-surgical management. Wrapping the gastric fundus around the distal esophagus, fundoplication, is a surgical technique that has long been practiced to treat GERD. Although the procedure has been proven to support the shutter mechanism of the esophagogastric junction, it comes with potential complications such as swallowing difficulty, gas bloating syndrome or dumpling syndrome. Smart patient selection, detailed pre-operative evaluation, precise technical tailoring and post-operative follow-up are key success factors that a care team should develop when considering this procedure. In addition, frontier technologies, such as transoral endoscopic fundoplication, robotic-assisted fundoplication and magnetic bead esophageal supporting device, are on their way to this arena.

References

Rybak A, Pesce M, Thapar N, et al. Gastro-esophageal reflux in children. Int J Mol Sci 2017;18:1671.doi:10.3390/ijms18081671.

Dahlen HG, Foster JP, Psaila K, et al. Gastro-oesophageal reflux: a mixed methods study of infants admitted to hospital in the first 12 months following birth in NSW (2000-2011). BMC Pediatr. 2018;18:30.doi:10.1186/s12887-018-0999-9.

Nelson SP, Chen EH, Syniar GM, et al. Prevalence of symptoms of gastroesophageal reflux during infancy. A pediatric practice-based survey. Pediatric Practice Research Group. Arch Pediatr Adolesc Med 1997;151:569-72.

Martin AJ, Pratt N, Kennedy JD, et al. Natural history and familial relationships of infant spilling to 9 years of age. Pediatrics. 2002;109:1061-7.

Miyazawa R, Tomomasa T, Kaneko H, et al. Prevalence of gastro-esophageal reflux-related symptoms in Japanese infants. Pediatr Int 2002;44:513-6.

Iacono G, Merolla R, D'Amico D, et al. Gastrointestinal symptoms in infancy: a population-based prospective study. Dig Liver Dis 2005;37:432-8.

Hegar B, Dewanti NR, Kadim M, et al. Natural evolution of regurgitation in healthy infants. Acta Paediatr 2009;98:1189-93.

Dhillon AS, Ewer AK. Diagnosis and management of gastro-oesophageal reflux in preterm infants in neonatal intensive care units. Acta Paediatr 2004;93:88-93.

Rosen R, Vandenplas Y, Singendonk M, et al. Pediatric Gastroesophageal Reflux Clinical Practice Guidelines: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr 2018;66:516-54.

Ruigomez A, Wallander MA, Lundborg P, et al. Gastroesophageal reflux disease in children and adolescents in primary care. Scand J Gastroenterol 2010;45:139-46.

Jackson HT, Kane TD. Surgical management of pediatric gastroesophageal reflux disease. Gastroenterol Res Pract 2013;2013:863527.doi: 10.1155/2013/863527.

Wilson GJ, van der Zee DC, Bax NM. Endoscopic gastrostomy placement in the child with gastroesophageal reflux: is concomitant antireflux surgery indicated? J Pediatr Surg 2006;41:1441-5.

Curien-Chotard M, Jantchou P. Natural history of gastroesophageal reflux in infancy: new data from a prospective cohort. BMC Pediatr 2020;20:152.doi:10.1186/s12887-020-02047-3.

Leung AA, Yamamoto J, Luca P, et al. Congenital bands with intestinal malrotation after propylthiouracil exposure in early pregnancy. Case Rep Endocrinol 2015;2015:789762.doi:10.1155/2015/789762.

Krishnan U, Mousa H, Dall'Oglio L, et al. ESPGHAN-NASPGHAN Guidelines for the evaluation and treatment of gastrointestinal and nutritional complications in children with esophageal atresia-tracheoesophageal fistula. J Pediatr Gastroenterol Nutr 2016;63:550-70.

Vergouwe FWT, van Wijk MP, Spaander MCW, et al. Evaluation of gastroesophageal reflux in children born with esophageal atresia using pH and impedance monitoring. J Pediatr Gastroenterol Nutr 2019;69:515-22.

Fernando T, Goldman RD. Management of gastroesophageal reflux disease in pediatric patients with cerebral palsy. Can Fam Physician 2019;65:796-8.

Malaty HM, Fraley JK, Abudayyeh S, et al. Obesity and gastroesophageal reflux disease and gastroesophageal reflux symptoms in children. Clin Exp Gastroenterol 2009;2:31-6.

Leung AK, Hon KL. Gastroesophageal reflux in children: an updated review. Drugs Context 2019;8:212591.doi:10.7573/dic.212591.

Baird DC, Harker DJ, Karmes AS. Diagnosis and Treatment of Gastroesophageal Reflux in Infants and Children. Am Fam Physician 2015;92:705-14.

Uslu Kizilkan N, Bozkurt MF, Saltik Temizel IN, et al. Comparison of multichannel intraluminal impedance-pH monitoring and reflux scintigraphy in pediatric patients with suspected gastroesophageal reflux. World J Gastroenterol 2016;22:9595-603.

Vane DW, Harmel RP, Jr., King DR, et al. The effectiveness of Nissen fundoplication in neurologically impaired children with gastroesophageal reflux. Surgery 1985;98:662-7.

AlNamshan MK, AlKharashi NM, Crankson SJ, et al. The outcomes of fundoplication and gastrostomy in neurologically impaired children in a tertiary care hospital in Saudi Arabia. Saudi Med J 2019;40:810-4.

Slater BJ, Rothenberg SS. Fundoplication. Clin Perinatol 2017;44:795-803.

Slater BJ, Rothenberg SS. Gastroesophageal reflux. Semin Pediatr Surg 2017;26:56-60.

Fults DW, Taussky P. The life of Rudolf Nissen: advancing surgery through science and principle. World J Surg 2011;35:1402-8.

Hakanson BS, Lundell L, Bylund A, et a. Comparison of laparoscopic 270 degrees posterior partial fundoplication vs total fundoplication for the treatment of gastroesophageal reflux disease: a randomized clinical trial. JAMA Surg 2019;154:479-86.

Nissen R. [A simple operation for control of reflux esophagitis]. Schweiz Med Wochenschr 1956;86(Suppl 20):590-2.

Toupet A. [Technic of esophago-gastroplasty with phrenogastropexy used in radical treatment of hiatal hernias as a supplement to Heller's operation in cardiospasms]. Mem Acad Chir (Paris) 1963;89:384-9.

Thal AP. A unified approach to surgical problems of the esophagogastric junction. Ann Surg 1968;168:542-50.

Boix-Ochoa J. The physiologic approach to the management of gastric esophageal reflux. J Pediatr Surg 1986;21:1032-9.

Richards WO, Torquati A, Holzman MD, et al. Heller myotomy versus Heller myotomy with Dor fundoplication for achalasia: a prospective randomized double-blind clinical trial. Ann Surg 2004;240:405-12.

Ishii D, Miyamoto K, Hirasawa M, et al. Preferential performance of Thal fundoplication for gastroesophageal reflux disease: a single institution experience. Pediatr Surg Int 2021;37:191-6.

Bell RC, Cadiere GB. Transoral rotational esophagogastric fundoplication: technical, anatomical, and safety considerations. Surg Endosc 2011;25:2387-99.

Robertson JO, Jarboe MD. Long-term outcomes of transoral incisionless fundoplication in a high-risk pediatric population. J Laparoendosc Adv Surg Tech A 2018;28:95-100.

Knatten CK, Kvello M, Fyhn TJ, et al. Nissen fundoplication in children with and without neurological impairment: a prospective cohort study. J Pediatr Surg 2016;51:1115-21.

Fonkalsrud EW. Nissen fundoplication for gastroesophageal reflux disease in infants and children. Semin Pediatr Surg 1998;7:110-4.

Esposito C, Montupet P, Amici G, et al. Complications of laparoscopic antireflux surgery in childhood. Surg Endosc 2000;14:622-4.

Rothenberg SS. Two decades of experience with laparoscopic nissen fundoplication in infants and children: a critical evaluation of indications, technique, and results. J Laparoendosc Adv Surg Tech A 2013;23:791-4.

Martin K, Deshaies C, Emil S. Outcomes of pediatric laparoscopic fundoplication: a critical review of the literature. Can J Gastroenterol Hepatol 2014;28:97-102.

Lopez-Fernandez S, Hernandez F, Hernandez-Martin S, et al. Failed Nissen fundoplication in children: causes and management. Eur J Pediatr Surg 2014;24:79-82.

Pellegrino SA, King SK, McLeod E, et al. Impact of esophageal atresia on the success of fundoplication for gastroesophageal reflux. J Pediatr 2018;198:60-6.

Snyder CL, Ramachandran V, Kennedy AP, et al. Efficacy of partial wrap fundoplication for gastroesophageal reflux after repair of esophageal atresia. J Pediatr Surg 1997;32:1089-91.

Tovar JA, Fragoso AC. Anti-reflux surgery for patients with esophageal atresia. Dis Esophagus 2013;26:401-4.

Rintala RJ. Fundoplication in patients with esophageal atresia: patient selection, indications, and outcomes. Front Pediatr 2017;5:109.doi:10.3389/fped.2017.00109.

Gezer HO, Ezer SS, Temiz A, et al. Partial fundoplication treats reflux, even in neurologically impaired patients. Can it take the title of "gold standard" from total fundoplication? J Gastrointest Surg 2019;23:2338-45.

Yamoto M, Fukumoto K, Takahashi T, et al. Risk factors of dumping syndrome after fundoplication for gastroesophageal reflux in children. Pediatr Surg Int 2021;37:183-9.

Kubiak R, Eaton S, Andrews J, et al. Long-term catch-up weight gain following fundoplication in children. Eur J Pediatr Surg 2013;23:121-6.

Barnhart DC, Hall M, Mahant S, et al. Effectiveness of fundoplication at the time of gastrostomy in infants with neurological impairment. JAMA Pediatr 2013;167:911-8.

Frongia G, Ahrens P, Capobianco I, et al. Long-term effects of fundoplication in children with chronic airway diseases. J Pediatr Surg 2015;50:206-10.

Capito C, Leclair MD, Piloquet H, et al. Long-term outcome of laparoscopic Nissen-Rossetti fundoplication for neurologically impaired and normal children. Surg Endosc 2008;22:875-80.

Kubiak R, Andrews J, Grant HW. Long-term outcome of laparoscopic nissen fundoplication compared with laparoscopic thal fundoplication in children: a prospective, randomized study. Ann Surg 2011;253:44-9.

Hu JM, Hu M, Wu YM, et al. Long-term outcome of laparoscopic Nissen-Rossetti fundoplication versus Thal fundoplication in children with esophageal hiatal hernia: a retrospective report from two children's medical centers in Shanghai. World J Pediatr 2016;12:231-5.

Rossi V, Mazzola C, Leonelli L, et al. Long-term outcome and need of re-operation in gastro-esophageal reflux surgery in children. Pediatr Surg Int 2016;32:277-83.

Gutt CN, Markus B, Kim ZG, et al. Early experiences of robotic surgery in children. Surg Endosc 2002;16:1083-6.

Heller K, Gutt C, Schaeff B, et al. Use of the robot system Da Vinci for laparoscopic repair of gastro-oesophageal reflux in children. Eur J Pediatr Surg 2002;12:239-42.

Anderberg M, Kockum CC, Arnbjornsson E. Robotic fundoplication in children. Pediatr Surg Int 2007;23:123-7.

Reiter MA, Young A, Adamson C. Decrease new graduate nurse orientation costs by using HESI exit exam scores. J Nurs Adm 2007;37:459-63.

Margaron FC, Oiticica C, Lanning DA. Robotic-assisted laparoscopic Nissen fundoplication with gastrostomy preservation in neurologically impaired children. J Laparoendosc Adv Surg Tech A 2010;20:489-92.

Cundy TP, Marcus HJ, Clark J, et al. Robot-assisted minimally invasive surgery for pediatric solid tumors: a systematic review of feasibility and current status. Eur J Pediatr Surg 2014;24:127-35.

Cundy TP, Harling L, Marcus HJ, et al. Meta analysis of robot-assisted versus conventional laparoscopic fundoplication in children. J Pediatr Surg 2014;49:646-52.

Ganz RA. The esophageal sphincter device for treatment of GERD. Gastroenterol Hepatol 2013;9:661-3.

Reynolds JL, Zehetner J, Wu P, et al. Laparoscopic magnetic sphincter augmentation vs laparoscopic Nissen fundoplication: a matched-pair analysis of 100 patients. J Am Coll Surg 2015;221:123-8.

Saino G, Bonavina L, Lipham JC, et al. Magnetic sphincter augmentation for gastroesophageal reflux at 5 years: final results of a pilot study show long-term acid reduction and symptom improvement. J Laparoendosc Adv Surg Tech A 2015;25:787-92.

Skubleny D, Switzer NJ, Dang J, et al. LINX® magnetic esophageal sphincter augmentation versus Nissen fundoplication for gastroesophageal reflux disease: a systematic review and meta-analysis. Surg Endosc 2017;31:3078-84.

Aiolfi A, Asti E, Bernardi D, et al. Early results of magnetic sphincter augmentation versus fundoplication for gastroesophageal reflux disease: systematic review and meta-analysis. Int J Surg 2018;52:82-8.

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Published

2022-09-30

How to Cite

1.
Uppakarn K, Laochareonsuk W, Sangkhathat S. Current Surgical Role in Pediatric Gastroesophageal Reflux. Thai J Surg [Internet]. 2022 Sep. 30 [cited 2024 May 15];43(3):88-96. Available from: https://he02.tci-thaijo.org/index.php/ThaiJSurg/article/view/255949

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Review Articles