Efficacy of Mosapride Citrate in Combination with Oral Mechanical Bowel Preparation for Colonoscopy
Keywords:
Mosapride citrate, Colonoscopy, Boston Bowel Preparation Scale, Polyethylene glycol, Sodium phosphate solutionAbstract
Objective: The present study aimed to evaluate the efficacy, in terms of bowel preparation quality, and safety of adjunctive mosapride citrate with oral mechanical bowel preparation for colonoscopy.
Methods: We conducted a randomized, controlled trial, mosapride in addition to mechanical bowel preparation. Of 330 patients undergoing colonoscopy, 158 were randomized to an additional 10 mg of mosapride citrate (intervention group) to oral mechanical bowel preparation, and 172 received only oral mechanical bowel preparation (control group). Patients completed questionnaires reporting the acceptability and tolerability of the bowel preparation process. The efficacy of bowel preparation was assessed by colonoscopists using a Boston Bowel Preparation Scale (BBPS).
Results: A total of 330 patients were included in the analysis. In the intervention group, optimal excellent bowel preparation rates were significantly higher compared with the control group (81.6% vs. 64.5%, p < 0.001). The incidence of adverse events was similar in both groups. Moreover, patients significantly favored intervention group over control, reflected by less clinical symptoms of nausea, abdominal pain, abdominal distension and willingness to repeat the same regimen
Conclusion: Mosapride citrate may be an effective and safe adjunct to oral mechanical bowel preparation for colonoscopy that leads to improve quality of bowel preparation and patient compliance.
References
Jang JY, Chun HJ. Bowel preparations as quality indicators for colonoscopy. World J Gastroenterol 2014;20:2746-50.
Hendry PO, Jenkins JT, Diament RH. The impact of poor bowel preparation on colonoscopy: a prospective single centre study of 10,571 colonoscopies. Colorectal Dis 2007;9:745-8.
Millien VO, Mansour NM. Bowel preparation for colonoscopy in 2020: a look at the past, present, and future. Curr Gastroenterol Rep 2020;6;22-8.
Jung IS, Kim JH, Lee HY, et al. Endoscopic evaluation of gastric emptying and effect of mosapride citrate on gastric emptying. Yonsei Med J 2010;51:33-8.
Kastenberg D, Bertiger G, Brogadir S. Bowel preparation quality scales for colonoscopy. World J Gastroenterol 2018;24:2833-43.
Kamei M, Shibuya T, Takahashi M, et al. Efficacy and acceptability of 1 Liter of polyethylene glycol with ascorbic acid vs. 2 Liters of polyethylene glycol plus mosapride and sennoside for colonoscopy preparation. Med Sci Monit 2018;24:523-30.
Abut E, Guveli H, Yasar B, et al. Administration of olive oil followed by a low volume of polyethylene glycol-electrolyte lavage solution improves patient satisfaction with right-side colonic cleansing over administration of the conventional volume of polyethylene glycol-electrolyte lavage solution for colonoscopy preparation. Gastrointest Endosc 2009;70:515-21.
Mine Y, Morikage K, Oku S, et al. Effect of mosapride citrate hydrate on the colon cleansing action of polyethylene glycol electrolyte lavage solution (PEG-ELS) in guinea pigs. J Pharmacol Sci 2009;110:415-23.
Mishima Y, Amano Y, Okita K, et al. Efficacy of prokinetic agents in improving bowel preparation for colonoscopy. Digestion 2008;77:166-72.
Tajika M, Niwa Y, Bhatia V, et al. Can mosapride citrate reduce the volume of lavage solution for colonoscopy preparation? World J Gastroenterol 2013;19:727-35.
Lee J, Jeong SJ, Kim TH, et al. Efficacy of mosapride citrate with a split dose of polyethylene glycol plus ascorbic acid for bowel preparation in elderly patients: A randomized controlled trial. Medicine 2020;99:e18702.
Mishima Y, Amano Y, Okita K, et al. Efficacy of prokinetic agents in improving bowel preparation for colonoscopy. Digestion 2008;77:166-72.
Tholey DM, Shelton CE, Francis G, et al. Adenoma detection in excellent versus good bowel preparation for colonoscopy. J Clin Gastroenterol 2015;49:313-19.
Oikawa T, Takemoto Y, Haramu K. Post-marketing surveillance of mosapride citrate (Gasmotin) in patients with nonulcer dyspepsia on long-term administration [in Japanese]. Rinsho Iyaku 2005;21:831-7.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 The Royal College of Surgeons of Thailand
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles must be contributed solely to The Thai Journal of Surgery and when published become the property of the Royal College of Surgeons of Thailand. The Royal College of Surgeons of Thailand reserves copyright on all published materials and such materials may not be reproduced in any form without the written permission.
