Survival Rate in Curative Resection of Gastric Cancer Patients at Maharat Nakhon Ratchasima Hospital
Keywords:
Gastric cancer, Survival rate, Prognostic factorsAbstract
Background: Gastric cancer still remains an important cancer because of the mortality rate of this lethal disease is high, this cancer has rapid progression and it is difficult to detect early stage. Survival rate is variety between geographically and accurate prognostic factors for gastric cancer are still limited.
Objective: The aim of this study was to evaluate survival rate and the clinicopathological factors associated with survival of gastric cancer patients.
Methods: Data of gastric cancer patients who underwent resection were collected from medical records between January 1, 2012 to December 31, 2016 (5 years). The primary outcome was overall survival by Kaplan-Meier method. Univariable and multivariable Cox proportional hazard regression analysis were performed to determine independent prognostic factors.
Results: Of 96 patients, mean age was 62.4 years, lower third was the most common tumor location, total gastrectomy was the most common procedure. The study demonstrated median survival time was 12.4 months and 1-year, 3-year, 5-year survival rates were 53%, 18%, and 12% respectively. Univariable Cox regression found that lymph node ratio (LNR) > 0.4 (HR 3.96, 95% CI 1.81-8.67, p = 0.001) and stage IV (HR 8.41, 95% CI 1.88-37.57, p = 0.005) were associated with poor survival. Multivariable Cox regression analyses showed that only staging IV (HR 9.02, 95% CI 1.35-60.20, p = 0.024) was significantly associated with survival.
Conclusion: Our study demonstrates that clinical stage IV is the independent prognostic factor associated with poor survival outcome.
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